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dc.contributor.authorDUMAN ÖZTÜRK, SEDA
dc.contributor.authorBEDİR, RECEP
dc.contributor.authorOKCU, OĞUZHAN
dc.contributor.authorAskan, Gokce
dc.contributor.authorSen, Bayram
dc.contributor.authorOzturk, Cigdem
dc.date.accessioned2023-10-10T10:38:58Z
dc.date.available2023-10-10T10:38:58Z
dc.identifier.citationOzturk C., OKCU O., DUMAN ÖZTÜRK S., Askan G., Sen B., BEDİR R., "A new practical method of estimating tumoral microenvironment parameters of possible prognostic significance in patients with invasive breast carcinoma: Combined microenvironment score", ANNALS OF DIAGNOSTIC PATHOLOGY, cilt.64, 2023
dc.identifier.issn1092-9134
dc.identifier.othervv_1032021
dc.identifier.otherav_08ffefcf-0ca6-4e2b-8dd7-61c54479c804
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189410
dc.identifier.urihttps://doi.org/10.1016/j.anndiagpath.2023.152128
dc.description.abstractBackground and objective: In recent years, the tumor microenvironment has become increasingly recognized as an influential factor in breast cancer development and growth. The parameters that form the microenvironment are the tumor stroma ratio and tumor infiltrating lymphocytes. In addition, tumor budding, which shows the ability of the tumor to metastasize, gives information about the progression of the tumor. In this study, the combined microenvironment score (CMS) was determined with these parameters, and the relationship between CMS and prognostic parameters and survival was evaluated.Materials and methods: In our study, tumor stroma ratio, tumor infiltrating lymphocytes, and tumor budding were evaluated in hematoxylin-eosin sections of 419 patients with invasive ductal carcinoma. Patients were scored separately for each of these parameters, and these scores were summed to determine the CMS. The patients were divided into 3 groups according to CMS and the relationship between CMS and prognostic parameters and the survival of the patients was studied.Results: The patients with CMS 3 had higher histological grade and Ki67 proliferation index compared to CMS and 2. Additionally, lymphovascular invasion, axillary lymph node and distant metastasis were more common. Disease-free, and overall survival were significantly shortened in the CMS 3 group. CMS was found as an in-dependent risk factor for DFS (HR: 2.144 (95 % CI: 1.219-3.77) p: 0.008), but not an independent risk factor for OS.Conclusion: CMS is a prognostic parameter that can be easily evaluated and does not require extra time and cost. Evaluating the morphological parameters of the microenvironment with a single scoring system will contribute to routine pathology practice and predict patient prognosis.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectPatoloji ve Adli Tıp
dc.subjectHistoloji
dc.subjectBiyokimya (tıbbi)
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBiyoloji ve Biyokimya
dc.subjectPATOLOJİ
dc.titleA new practical method of estimating tumoral microenvironment parameters of possible prognostic significance in patients with invasive breast carcinoma: Combined microenvironment score
dc.typeMakale
dc.relation.journalANNALS OF DIAGNOSTIC PATHOLOGY
dc.contributor.departmentRecep Tayyip Erdoğan Üniversitesi , ,
dc.identifier.volume64
dc.contributor.firstauthorID4310202


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