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dc.contributor.authorGÖKÖZ, ÖZAY
dc.contributor.authorNASIR, SERDAR NAZİF
dc.contributor.authorOzdemir, Fethiye Damla Menku
dc.contributor.authorUZUN, HAKAN
dc.contributor.authorYeniceri, Berna
dc.contributor.authorAksoyler, Dicle Yaşar
dc.contributor.authorBitik, Ozan
dc.date.accessioned2023-10-10T11:08:04Z
dc.date.available2023-10-10T11:08:04Z
dc.date.issued2021
dc.identifier.citationAksoyler D. Y., Bitik O., Ozdemir F. D. M., GÖKÖZ Ö., UZUN H., Yeniceri B., NASIR S. N., "A New Experimental Lymphedema Model Reevaluating the Efficacy of Rat Models and Their Clinical Translation for Chronic Lymphedema Studies", ANNALS OF PLASTIC SURGERY, cilt.86, sa.6, ss.707-713, 2021
dc.identifier.issn0148-7043
dc.identifier.otherav_11a89aa9-4be1-4bb1-9967-2c9d0f96856a
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189665
dc.identifier.urihttps://doi.org/10.1097/sap.0000000000002479
dc.description.abstractBackground Our aim was to create a new rodent hind limb lymphedema model lacking the fibrosis effect induced by radiotherapy and subjected to the inhibition of lymphangiogenesis via sirolimus (rapamycin) to maintain a chronic lymphedema model and investigate its reliability for human treatment modalities. Methods Forty-two Sprague-Dawley rats were randomly assigned to 7 groups: (1) surgery control, (2) vehicle-surgery control, (3) vehicle control, (4) rapamycin control, (5) surgery with 1 mg/kg per day rapamycin, (6) surgery with 1.5 mg/kg per day rapamycin, and (7) surgery with 2 mg/kg per day rapamycin. All surgeries were performed on the right hind limbs, with the left hind limbs also considered as a control. The drug and its solvent were administered daily into the relevant groups intraperiteonally. The presence of lymphedema was investigated by weekly limb circumference measurements, microcomputed tomography, fluorescence lymphography using indocyanine green dye, and microscopic evaluation at the end of the sixth week to determine any histological changes in the hind limbs. Results In group 1, lymphedema was observed for 2 weeks (P = 0.032), whereas in groups 5, 6, and 7, lymphedema lasted for 3 weeks (P 3 weeks. Because of the rapid neolymphangiogenesis in murines and a different wound healing mechanism, they should not be considered as an appropriate model for research on human lymphedema in first place.
dc.language.isoeng
dc.subjectCerrahi
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.titleA New Experimental Lymphedema Model Reevaluating the Efficacy of Rat Models and Their Clinical Translation for Chronic Lymphedema Studies
dc.typeMakale
dc.relation.journalANNALS OF PLASTIC SURGERY
dc.contributor.departmentChina Medical University Taiwan , ,
dc.identifier.volume86
dc.identifier.issue6
dc.identifier.startpage707
dc.identifier.endpage713
dc.contributor.firstauthorID4403666


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