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dc.contributor.authorZhang, Elizabeth
dc.contributor.authorYoshida, Tomoko
dc.contributor.authorStanwicks, Lauren
dc.contributor.authorGraybiel, Ann M.
dc.contributor.authorCima, Michael J.
dc.contributor.authorLanger, Robert
dc.contributor.authorDagdeviren, Hüseyin Emre
dc.contributor.authorAmemori, Satoko
dc.contributor.authorSchwerdt, Helen N.
dc.contributor.authorKim, Min Jung
dc.date.accessioned2023-10-10T12:11:49Z
dc.date.available2023-10-10T12:11:49Z
dc.identifier.citationSchwerdt H. N., Zhang E., Kim M. J., Yoshida T., Stanwicks L., Amemori S., Dagdeviren H. E., Langer R., Cima M. J., Graybiel A. M., "Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model", COMMUNICATIONS BIOLOGY, cilt.1, 2018
dc.identifier.issn2399-3642
dc.identifier.otherav_1c094234-6732-444d-9451-d47944c3e793
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189963
dc.identifier.urihttps://doi.org/10.1038/s42003-018-0147-y
dc.description.abstractChemical signaling underlies both temporally phasic and extended activity in the brain. Phasic activity can be monitored by implanted sensors, but chronic recording of such chemical signals has been difficult because the capacity to measure them degrades over time. This degradation has been attributed to tissue damage progressively produced by the sensors and failure of the sensors themselves. We report methods that surmount these problems through the development of sensors having diameters as small as individual neuronal cell bodies (<10 mu m). These micro-invasive probes (mu IPs) markedly reduced expression of detectable markers of inflammation and tissue damage in a rodent test model. The chronically implanted mu IPs provided stable operation in monitoring sub-second fluctuations in stimulation-evoked dopamine in anesthetized rats for over a year. These findings demonstrate that monitoring of chemical activity patterns in the brain over at least year-long periods, long a goal of both basic and clinical neuroscience, is achievable.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectBiyokimya (tıbbi)
dc.subjectMultidisipliner
dc.subjectTıp
dc.subjectTıbbi Biyoloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectBİYOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectTemel Bilimler (SCI)
dc.titleCellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model
dc.typeMakale
dc.relation.journalCOMMUNICATIONS BIOLOGY
dc.contributor.departmentAshridge Consulting Limited , ,
dc.identifier.volume1
dc.contributor.firstauthorID4552058


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