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dc.contributor.authorSever, Mehmet Şükrü
dc.contributor.authorOTO, Özgür Akın
dc.date.accessioned2023-10-10T12:15:53Z
dc.date.available2023-10-10T12:15:53Z
dc.date.issued2023
dc.identifier.citationOTO Ö. A., Sever M. Ş., "THE KIDNEY AT RISK: UNDERSTANDING CRUSH SYNDROME-RELATED ACUTE KIDNEY INJURY RİSK ALTINDAKİ BÖBREK: EZİLME SENDROMUNA BAĞLI AKUT BÖBREK HASARI", Istanbul Tip Fakultesi Dergisi, cilt.86, sa.3, ss.245-253, 2023
dc.identifier.issn1305-6433
dc.identifier.otherav_1d3d7b31-bb55-410e-af08-bb8484b45a75
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189997
dc.identifier.urihttps://doi.org/10.26650/iuitfd.1297993
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85167424813&origin=inward
dc.description.abstractCrush syndrome (systemic manifestations of traumatic rhabdomyolysis) is the second leading cause of death after earthquakes or other destructive disasters. Crush-related acute kidney injury (AKI) is the most important Component of crush syndrome, and medical professionals living in disaster-prone regions should know about its pathophysiology, clinical and laboratory features, complications, and treatment. Pathogenesis of AKI on the basis of crush injuries is multifaceted. The most important mechanism is compartment syndrome-related hypovolemia, and consequent renal hypoperfusion, which may result in ischemic acute tubular necrosis. Also, rhabdomyolysis-related myoglobinuria may result in the formation of kidney-damaging myoglobin casts and direct tubular toxicity. Formation of uric acid plugs, oxidant injury, increased serum levels of cytokines, and still many other factors may take a role in the pathogenesis as well. Crush syndrome can cause serious electrolyte imbalances, sepsis, and bleeding, which can further exacerbate AKI. Early recognition and appropriate management, which includes aggressive hydration and management of electrolyte imbalances can help to prevent or minimize kidney damage. This review provides an overview of the pathophysiology, complications, and treatment of AKI in the context of Crush syndrome.
dc.language.isoeng
dc.subjectTıp
dc.subjectGenel Tıp
dc.subjectSağlık Bilimleri
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTemel Tıp Bilimleri
dc.titleTHE KIDNEY AT RISK: UNDERSTANDING CRUSH SYNDROME-RELATED ACUTE KIDNEY INJURY RİSK ALTINDAKİ BÖBREK: EZİLME SENDROMUNA BAĞLI AKUT BÖBREK HASARI
dc.typeMakale
dc.relation.journalIstanbul Tip Fakultesi Dergisi
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü
dc.identifier.volume86
dc.identifier.issue3
dc.identifier.startpage245
dc.identifier.endpage253
dc.contributor.firstauthorID4514675


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