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dc.contributor.authorKalaycı, Rivaze
dc.contributor.authorBingül, İlknur
dc.contributor.authorBekpınar, Seldağ
dc.contributor.authorSoluk Tekkeşin, Merva
dc.contributor.authorOlgaç, Necat Vakur
dc.contributor.authorUysal, Mujdat
dc.date.accessioned2023-10-10T12:25:14Z
dc.date.available2023-10-10T12:25:14Z
dc.identifier.citationKalaycı R., Bingül İ., Soluk Tekkeşin M., Olgaç N. V., Bekpınar S., Uysal M., "The effect of glycine on oxidative stress, inflammation and renin-angiotensin system in kidneys and aorta of cyclosporine-administered rats", DRUG AND CHEMICAL TOXICOLOGY, 2023
dc.identifier.issn0148-0545
dc.identifier.othervv_1032021
dc.identifier.otherav_200d1bc8-c974-401c-9f38-7261574ac2fc
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190076
dc.identifier.urihttps://doi.org/10.1080/01480545.2023.2219036
dc.description.abstractCyclosporine A (CsA) is an immunosuppressive drug, used in organ transplantations. Oxidative stress, inflammation and renin-angiotensin system (RAS) activation play an important role in CsA-toxicity. Glycine (Gly) has antioxidant and anti-inflammatory effects. In this study, Gly was investigated for its protective role against CsA-induced toxicity. CsA (20 mg/kg/day; subcutaneously) was administered to rats along with Gly injection (250 or 1000 mg/kg; intraperitoneally) for 21 days. Renal function markers [serum urea and creatinine and urinary protein and kidney injury molecule levels and creatinine clearance values] together with histopathological examinations were performed. Oxidative stress (reactive oxygen species, thiobarbutiric acid reactive substances, advanced oxidation products of protein, glutathione, ferric reducing anti-oxidant power and 4-hydroxynonenal levels), and inflammation (myeloperoxidase activity) were determined in kidney tissue. The RAS system [angiotensin II (Ang II) levels, and mRNA expressions of angiotensin converting enzyme (ACE), angiotensin II type-I receptor (AT1R)] and NADPH-oxidase 4 (NOX4) were measured in kidney and aorta. CsA caused significant disturbances in renal function markers, increases in oxidative stress and inflammation parameters and renal damage. Serum angiotensin II levels and mRNA expressions of ACE, AT1R and NOX4 elevated in the aorta and kidney of CsA-rats. Gly, especially its high-dose, alleviated renal function markers, oxidative stress, inflammation and renal damage in CsA-rats. Moreover, serum Ang II levels and mRNA expressions of ACE, AT1R and NOX4 decreased significantly in aorta and kidney in CsA-rats due to Gly treatment. Our results indicate that Gly may be useful for the prevention of CsA-induced renal and vascular toxicity.
dc.language.isoeng
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectSağlık, Toksikoloji ve Mutajenez
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectFarmasötik Toksikoloji
dc.subjectFizik Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectToksikoloji
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectKimya
dc.subjectTemel Bilimler (SCI)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTOKSİKOLOJİ
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectMeslek Bilimleri
dc.subjectFarmakoloji
dc.titleThe effect of glycine on oxidative stress, inflammation and renin-angiotensin system in kidneys and aorta of cyclosporine-administered rats
dc.typeMakale
dc.relation.journalDRUG AND CHEMICAL TOXICOLOGY
dc.contributor.departmentİstanbul Üniversitesi , Onkoloji Enstitüsü , Teşhis Tedavi Ve Bakım Hizmetleri
dc.contributor.firstauthorID4304568


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