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dc.contributor.authorOnder, Semen
dc.contributor.authorOzmen, Vahit
dc.contributor.authorSaip, Pinar
dc.contributor.authorCabioglu, Neslihan
dc.contributor.authorİBİŞ, Kamuran
dc.contributor.authorIgci, Abdullah
dc.contributor.authorAydiner, Adnan
dc.contributor.authorDOĞAN, İzzet
dc.contributor.authorAydin, Esra
dc.contributor.authorKHANMAMMADOV, Nıjat
dc.contributor.authorPaksoy, Nail
dc.contributor.authorFerhatoğlu, Ferhat
dc.contributor.authorAK, Naziye
dc.contributor.authorEmiroglu, Selman
dc.contributor.authorTukenmez, Mustafa
dc.contributor.authorKucucuk, Seden
dc.contributor.authorMuslumanoğlu, Mahmut
dc.date.accessioned2023-10-10T12:31:18Z
dc.date.available2023-10-10T12:31:18Z
dc.identifier.citationDOĞAN İ., Aydin E., KHANMAMMADOV N., Paksoy N., Ferhatoğlu F., AK N., Emiroglu S., İBİŞ K., Onder S., Tukenmez M., et al., "Long-term outcomes and predictors of recurrence in node-negative early stage breast cancer patients", Journal of Cancer Research and Clinical Oncology, 2023
dc.identifier.issn0171-5216
dc.identifier.otherav_2205d1f1-af82-4f6a-b019-0e62bb164bcb
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190129
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85168324487&origin=inward
dc.identifier.urihttps://doi.org/10.1007/s00432-023-05276-y
dc.description.abstractBackground: We evaluated the outcomes, and risk factors for recurrence in patients with early stage node-negative breast cancer in this study. Method: Retrospective data analysis was done on patient treatment records from 1988 to 2018. The patient’s demographic, clinical, pathological, and therapeutic characteristics were noted. To evaluate survival analysis and predictors of recurrence, we employed Kaplan–Meier analysis with the log-rank test. Results: A total of 357 patients in all were enrolled in the research. At the time of diagnosis, the median age was 50 (with a range of 18–81). A total of 85.5% of patients had undergone a lumpectomy, while 14.5% had a mastectomy. 78.7% of patients had sentinel lymph node biopsy, and 21.3% had axillary lymph node dissection. In addition, the patients received adjuvant radiotherapy (88.7%), adjuvant endocrine therapy (82.1%), and adjuvant chemotherapy (48.5%). Recurrence of the tumor occurred in 31 (8.7%) patients (local recurrence 45.2% and metastatic disease 54.8%). Ten- and twenty-year recurrence-free survival rates were 92% and 77%. 19 (5.3%) patients had also developed contralateral breast cancer. Ten-year survival rates were 91.6%, and 20-year survival rates were 76.6%, respectively. Aged over 65 years (p = 0.004), necrosis (p = 0.002), mitosis (p = 0.003), and nuclear pleomorphism (p = 0.049) were found as statistically significant factors for recurrence in univariate analysis. In the ROC analysis, the largest size of the tumor (over 1.45 cm, p = 0.07) remained outside the statistical significance limit in terms of recurrence. Conclusions: Thirty-year outcomes in individuals with early stage, node-negative breast cancer were shown in this study. We found that the recurrence ratios between 10 and 20 years were more frequent than the first 10 years during the follow-up. Despite the small number of patients who experienced a recurrence, we demonstrated that, in univariate analysis, being older than 65 and having some pathological characteristics (nuclear pleomorphism, mitosis, and necrosis) were statistically significant factors for disease recurrence.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectYaşam Bilimleri
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectKanser Araştırmaları
dc.subjectONKOLOJİ
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectKlinik Tıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp (MED)
dc.subjectMoleküler Biyoloji ve Genetik
dc.titleLong-term outcomes and predictors of recurrence in node-negative early stage breast cancer patients
dc.typeMakale
dc.relation.journalJournal of Cancer Research and Clinical Oncology
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Cerrahi Tıp Bilimleri Bölümü
dc.contributor.firstauthorID4543555


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