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dc.contributor.authorAKINCI, Ayşe Burcu
dc.contributor.authorKARADAŞ, NİHAL
dc.contributor.authorUnuvar, Aysegul
dc.contributor.authorGuzelkucuk, Zeliha
dc.contributor.authorYILMAZ KARAPINAR, DENİZ
dc.contributor.authorAYLAN GELEN, SEMA
dc.contributor.authorTokgoz, Huseyin
dc.contributor.authorÖZCAN, ALPER
dc.contributor.authorAY, YILMAZ
dc.contributor.authorBAHADIR, AYŞENUR
dc.contributor.authorOzbek, Namik Yasar
dc.contributor.authorOren, Ayse Ceyda
dc.contributor.authorCANBOLAT AYHAN, AYLİN
dc.contributor.authorAKYAY, ARZU
dc.contributor.authorÖREN, HALE
dc.contributor.authorFettah, Ali
dc.contributor.authorKAYA, ZÜHRE
dc.contributor.authorIsik, Bilgen
dc.contributor.authorEKER, İBRAHİM
dc.contributor.authorKARAMAN, Serap
dc.contributor.authorYILDIRIM, AYŞEN TÜREDİ
dc.contributor.authorOrhan, Mehmet Fatih
dc.contributor.authorOymak, Yesim
dc.contributor.authorTimur, Cetin
dc.contributor.authorYazici, Nalan
dc.contributor.authorSimsek, Ayse
dc.contributor.authorKarakurt, Neslihan
dc.contributor.authorTÖRET, ERSİN
dc.contributor.authorSEZGİN EVİM, MELİKE
dc.date.accessioned2023-10-10T12:47:32Z
dc.date.available2023-10-10T12:47:32Z
dc.date.issued2023
dc.identifier.citationGuzelkucuk Z., YILMAZ KARAPINAR D., AYLAN GELEN S., Tokgoz H., ÖZCAN A., AY Y., BAHADIR A., Ozbek N. Y., Oren A. C., CANBOLAT AYHAN A., et al., "Central nervous system thrombosis in pediatric acute lymphoblastic leukemia in Turkey: A multicenter study", PEDIATRIC BLOOD & CANCER, cilt.70, sa.8, 2023
dc.identifier.issn1545-5009
dc.identifier.otherav_25ff087a-08e0-48ca-aaa8-6acf9baa6f73
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190252
dc.identifier.urihttps://doi.org/10.1002/pbc.30425
dc.description.abstractBackgroundIn patients with acute lymphoblastic leukemia (ALL), the risk of thromboembolism increases due to hemostatic changes secondary to the primary disease and due to treatment-related factors. In this multicenter study, we aimed to research the frequency of central nervous system (CNS) thrombosis occurring during treatment, hereditary and acquired risk factors, clinical and laboratory features of patients with thrombosis, treatment approaches, and thrombosis-related mortality and morbidity rates in pediatric ALL patients. ProcedurePediatric patients who developed CNS thrombosis during ALL treatment from 2010 to 2021 were analyzed retrospectively in 25 different Pediatric Hematology Oncology centers in Turkiye. The demographic characteristics of the patients, symptoms associated with thrombosis, the stage of the leukemia treatment during thrombosis, the anticoagulant therapy applied for thrombosis, and the final status of the patients recorded through electronic medical records were determined. ResultsData from 70 patients with CNS thrombosis during treatment, out of 3968 pediatric patients with ALL, were reviewed. The incidence of CNS thrombosis was 1.8% (venous: 1.5 %; arterial: 0.03%). Among patients with CNS thrombosis, 47 had the event in the first 2 months. Low molecular weight heparin (LMWH) was the most commonly used treatment with a median of 6 months (min-max: 3-28 months). No treatment-related complications occurred. Chronic thrombosis findings occurred in four patients (6%). In five (7%) patients who developed cerebral vein thrombosis, neurological sequelae (epilepsy and neurological deficit) remained. One patient died related to thrombosis, and the mortality rate was 1.4%. ConclusionCerebral venous thrombosis and, less frequently, cerebral arterial thrombosis may develop in patients with ALL. The incidence of CNS thrombosis is higher during induction therapy than during other courses of treatment. Therefore, patients receiving induction therapy should be monitored carefully for clinical findings suggestive of CNS thrombosis.
dc.language.isoeng
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectHEMATOLOJİ
dc.subjectPEDİATRİ
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectHematoloji
dc.subjectOnkoloji
dc.subjectSağlık Bilimleri
dc.subjectPediatri
dc.titleCentral nervous system thrombosis in pediatric acute lymphoblastic leukemia in Turkey: A multicenter study
dc.typeMakale
dc.relation.journalPEDIATRIC BLOOD & CANCER
dc.contributor.departmentAnkara Bilkent City Hosp , ,
dc.identifier.volume70
dc.identifier.issue8
dc.contributor.firstauthorID4315285


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