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dc.contributor.authorNguyen, Quang
dc.contributor.authorCeker, Gokhan
dc.contributor.authorYazbeck, Chadi
dc.contributor.authorRajmil, Osvaldo
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorAltay, Baris
dc.contributor.authorBarrett, Trenton L.
dc.contributor.authorNgoo, Kay Seong
dc.contributor.authorRoychoudhury, Shubhadeep
dc.contributor.authorSalvio, Gianmaria
dc.contributor.authorLin, Haocheng
dc.contributor.authorTimpano, Massimiliano
dc.contributor.authorAvidor-Reiss, Tomer
dc.contributor.authorHakim, Lukman
dc.contributor.authorSindhwani, Puneet
dc.contributor.authorFranco, Giorgio
dc.contributor.authorSingh, Rajender
dc.contributor.authorGiacone, Filippo
dc.contributor.authorRuzaev, Mikhail
dc.contributor.authorKosgi, Raghavender
dc.contributor.authorSofikitis, Nikolaos
dc.contributor.authorPalani, Ayad
dc.contributor.authorÇALIK, Gökhan
dc.contributor.authorKulaksiz, Deniz
dc.contributor.authorJezek, Davor
dc.contributor.authorAl Hashmi, Manaf
dc.contributor.authorDrakopoulos, Panagiotis
dc.contributor.authorOmran, Huda
dc.contributor.authorLeonardi, Sofia
dc.contributor.authorCelik-Ozenci, Ciler
dc.contributor.authorGungor, Nur Dokuzeylul
dc.contributor.authorRamsay, Jonathan
dc.contributor.authorAmano, Toshiyasu
dc.contributor.authorSogutdelen, Emrullah
dc.contributor.authorDuarsa, Gede Wirya Kusuma
dc.contributor.authorChiba, Koji
dc.contributor.authorJindal, Sunil
dc.contributor.authorSavira, Missy
dc.contributor.authorBoeri, Luca
dc.contributor.authorBorges, Edson
dc.contributor.authorGupte, Deepak
dc.contributor.authorGokalp, Fatih
dc.contributor.authorHebrard, Guadalupe Hernandez
dc.contributor.authorMinhas, Suks
dc.contributor.authorShah, Rupin
dc.contributor.authorKADIOĞLU, Ateş
dc.contributor.authorFarkouh, Ala'a
dc.contributor.authorAgarwal, Ashok
dc.contributor.authorHamoda, Taha Abo-Almagd Abdel-Meguid
dc.contributor.authorKavoussi, Parviz
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorAmar, Edouard
dc.contributor.authorZini, Armand
dc.contributor.authorArafa, Mohamed
dc.contributor.authorHarraz, Ahmed M.
dc.contributor.authorGul, Murat
dc.contributor.authorKarthikeyan, Vilvapathy Senguttuvan
dc.contributor.authorDurairajanayagam, Damayanthi
dc.contributor.authorRambhatla, Amarnath
dc.contributor.authorBoitrelle, Florence
dc.contributor.authorChung, Eric
dc.contributor.authorBirowo, Ponco
dc.contributor.authorToprak, Tuncay
dc.contributor.authorAbou Ghayda, Ramy
dc.contributor.authorCannarella, Rossella
dc.contributor.authorPhuoc, Nguyen Ho Vinh
dc.contributor.authorDimitriadis, Fotios
dc.contributor.authorRusso, Giorgio
dc.contributor.authorSokolakis, Ioannis
dc.contributor.authorMostafa, Taymour
dc.contributor.authorMakarounis, Konstantinos
dc.contributor.authorZiouziou, Imad
dc.contributor.authorKuroda, Shinnosuke
dc.contributor.authorBendayan, Marion
dc.contributor.authorKaiyal, Raneen Sawaid
dc.contributor.authorJapari, Andrian
dc.contributor.authorSimopoulou, Mara
dc.contributor.authorRocco, Lucia
dc.contributor.authorGarrido, Nicolas
dc.contributor.authorGherabi, Nazim
dc.contributor.authorBocu, Kadir
dc.contributor.authorKahraman, Oguzhan
dc.contributor.authorLe, Tan
dc.contributor.authorWyns, Christine
dc.contributor.authorTremellen, Kelton
dc.contributor.authorSarikaya, Selcuk
dc.contributor.authorLewis, Sheena
dc.contributor.authorEvenson, Donald P.
dc.contributor.authorKo, Edmund
dc.contributor.authorCalogero, Aldo E.
dc.contributor.authorBahar, Fahmi
dc.contributor.authorMartinez, Marlon
dc.contributor.authorCrafa, Andrea
dc.contributor.authorAmbar, Rafael F.
dc.contributor.authorColpi, Giovanni
dc.contributor.authorBakircioglu, Mustafa Emre
dc.contributor.authorHenkel, Ralf
dc.contributor.authorKandil, Hussein
dc.contributor.authorSerefoglu, Ege Can
dc.contributor.authorAlarbid, Abdullah
dc.contributor.authorTsujimura, Akira
dc.contributor.authorKheradmand, Alireza
dc.contributor.authorAnagnostopoulou, Christina
dc.contributor.authorMarino, Angelo
dc.contributor.authorAdamyan, Aram
dc.contributor.authorZilaitiene, Birute
dc.contributor.authorÖZER, CEVAHİR
dc.contributor.authorPescatori, Edoardo
dc.contributor.authorVogiatzi, Paraskevi
dc.contributor.authorBusetto, Gian Maria
dc.contributor.authorBalercia, Giancarlo
dc.contributor.authorElbardisi, Haitham
dc.contributor.authorAkhavizadegan, Hamed
dc.contributor.authorSajadi, Hesamoddin
dc.contributor.authorTaniguchi, Hisanori
dc.contributor.authorPark, Hyun Jun
dc.contributor.authorRosas, Israel Maldonado
dc.contributor.authorAl-Marhoon, Mohamed
dc.contributor.authorGilani, Mohammad Ali Sadighi
dc.contributor.authorAlhathal, Naif
dc.contributor.authorPinggera, Germar-Michael
dc.contributor.authorKothari, Priyank
dc.contributor.authorMogharabian, Nasser
dc.contributor.authorMicic, Sava
dc.contributor.authorHoma, Sheryl
dc.contributor.authorDarbandi, Sara
dc.contributor.authorLong, Tran Quang Tien
dc.contributor.authorZohdy, Wael
dc.contributor.authorAtmoko, Widi
dc.contributor.authorSabbaghian, Marjan
dc.contributor.authorIbrahim, Wael
dc.contributor.authorSmith, Ryan P.
dc.contributor.authorHo, Christopher Chee Kong
dc.contributor.authorde la Rosette, Jean
dc.contributor.authorEl-Sakka, Ahmed I.
dc.contributor.authorPreto, Mirko
dc.contributor.authorZenoaga-Barbarosie, Catalina
dc.contributor.authorAbumelha, Saad Mohammed
dc.contributor.authorBaser, Aykut
dc.contributor.authorAYDOS, KAAN
dc.contributor.authorRamirez-Dominguez, Liliana
dc.contributor.authorKumar, Vijay
dc.contributor.authorOng, Teng Aik
dc.contributor.authorMierzwa, Tiago Cesar
dc.contributor.authorAdriansjah, Ricky
dc.contributor.authorBanihani, Saleem A.
dc.contributor.authorBowa, Kasonde
dc.contributor.authorFukuhara, Shinichiro
dc.contributor.authorPena, Marcelo Rodriguez
dc.contributor.authorMoussa, Mohamad
dc.contributor.authorARI, UMUT ÇAĞIN
dc.contributor.authorCho, Chak-Lam
dc.contributor.authorTadros, Nicholas N.
dc.contributor.authorUgur, Muhammet Rasit
dc.contributor.authorFalcone, Marco
dc.contributor.authorSanter, Frederic Romain
dc.contributor.authorKalkanli, Arif
dc.contributor.authorKarna, Keshab Kumar
dc.contributor.authorKhalafalla, Kareim
dc.contributor.authorVishwakarma, Ranjit B.
dc.contributor.authorFinocchi, Federica
dc.contributor.authorGiulioni, Carlo
dc.contributor.authorCeyhan, Erman
dc.date.accessioned2023-10-10T12:48:30Z
dc.date.available2023-10-10T12:48:30Z
dc.identifier.citationFarkouh A., Agarwal A., Hamoda T. A. A., Kavoussi P., Saleh R., Zini A., Arafa M., Harraz A. M., Gul M., Karthikeyan V. S., et al., "Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations", WORLD JOURNAL OF MENS HEALTH, 2023
dc.identifier.issn2287-4208
dc.identifier.otherav_266b0bd0-b0e5-407e-b588-97aa7fa16664
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190265
dc.identifier.urihttps://doi.org/10.5534/wjmh.230008
dc.description.abstractPurpose: Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproduc-tive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. Materials and Methods: An online global survey on clinical practices related to SDF was disseminated to reproductive clini-cians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formu-lated and adapted using the Delphi method.Results: A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4-6 months and 38.1% recommend 3 months. For men with unex-plained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respon-dents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical vari-cocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated.Conclusions: This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians.
dc.language.isoeng
dc.subjectANDROLOJİ
dc.subjectDahili Tıp Bilimleri
dc.subjectAile Hekimliği
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectNefroloji
dc.subjectSağlık Bilimleri
dc.subjectTıbbi Terminoloji
dc.subjectTıbbi Sekreterlik ve Transkripsiyon
dc.subjectSağlık Bilgi Yönetimi
dc.subjectSağlık Meslekleri (çeşitli)
dc.subjectGözden Geçirme ve Sınav Hazırlığı
dc.subjectLiderlik ve Yönetim
dc.subjectToplum Sağlığı ve Evde Bakım
dc.subjectBakım Planlaması
dc.subjectEndokrin ve Otonom Sistemler
dc.subjectÜroloji
dc.subjectÜreme Tıbbı
dc.subjectSağlık Politikaları
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectEndokrinoloji
dc.subjectYaşam Bilimleri
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectSAĞLIK BAKIM BİLİMLERİ VE HİZMETLERİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTıp
dc.titleControversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
dc.typeMakale
dc.relation.journalWORLD JOURNAL OF MENS HEALTH
dc.contributor.departmentAmer Ctr Reprod Med , ,
dc.contributor.firstauthorID4315411


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