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dc.contributor.authorKARAVUŞ, Şule Nur
dc.contributor.authorKARADAĞ, Ayşe Esra
dc.contributor.authorBİLTEKİN KALELİ, Sevde Nur
dc.contributor.authorHelvaci, Esra Zeynep
dc.contributor.authorÇAŞKURLU, Ayşegül
dc.date.accessioned2023-10-10T12:49:24Z
dc.date.available2023-10-10T12:49:24Z
dc.date.issued2023
dc.identifier.citationÇAŞKURLU A., KARAVUŞ Ş. N., BİLTEKİN KALELİ S. N., Helvaci E. Z., KARADAĞ A. E., "In vitro cytotoxicity evaluation and phytochemical analysis of Ajuga reptans L. extracts", Journal of Research in Pharmacy, cilt.27, sa.5, ss.2115-2123, 2023
dc.identifier.issn2630-6344
dc.identifier.othervv_1032021
dc.identifier.otherav_26b87daa-317e-4cd3-bf2f-fbf3591f1d3b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190276
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171836463&origin=inward
dc.identifier.urihttps://doi.org/10.29228/jrp.2022.00
dc.description.abstractThe aim of this study was to evaluate phytochemical composition of Ajuga reptans L. (Lamiaceae) aerial parts (separately flower and leaf) methanol, aqueous-methanolic extracts, and their cytotoxic activities. The phytochemical analysis was performed high-performance liquid chromatography (HPLC). Caffeic acid, p-coumaric, gallic, chlorogenic, ferulic acids, kaempferol, rutin, quercetin, quercetin-3-O-galactoside, and quercitrin were used as reference substances by HPLC in all samples. The major compounds in the extract were found as ferulic acid, caffeic acid, rutin, and quercetin-3-O-galactoside. Cytotoxicity was investigated using methyl thiazole tetrazolium (MTT) assay. Cytotoxic evaluation of the extracts against cancer (MCF7, PC3, and A549) and healthy human embryonic kidney cell line (HEK293) cell lines by MTT. Compared to other cells, the methanol extract of A. reptans demonstrated high selectivity against PC3 cells (IC50: 95 ± 0.99 µg/mL) and selectivity index was four times higher than reference drug colchicine. (IC50: 95 ± 0.99 µg/mL, SI: 6.10). A. reptans demonstrated antiproliferative potential against prostate and lung cancer cells. Therefore, additional investigations are needed to study the mechanism of the cytotoxicity for A. reptans.
dc.language.isoeng
dc.subjectFarmakoloji (tıbbi)
dc.subjectYaşam Bilimleri
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.titleIn vitro cytotoxicity evaluation and phytochemical analysis of Ajuga reptans L. extracts
dc.typeMakale
dc.relation.journalJournal of Research in Pharmacy
dc.contributor.departmentİstanbul Medipol Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü
dc.identifier.volume27
dc.identifier.issue5
dc.identifier.startpage2115
dc.identifier.endpage2123
dc.contributor.firstauthorID4572888


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