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dc.contributor.authorDehnavi, Ali Zare
dc.contributor.authorNaeini, Alireza Ranjbar
dc.contributor.authorAhmadzade, Ali
dc.contributor.authorFarahani, Ramin Hamidi
dc.contributor.authorAminianfar, Mohammad
dc.contributor.authorRahmani, Mohammad
dc.contributor.authorMoghadasi, Abdorreza Naser
dc.contributor.authorShahi, Shayan
dc.contributor.authorEskandarieh, Sharareh
dc.contributor.authorAzizi, HOSSEIN
dc.contributor.authorHasanzadeh, Alireza
dc.date.accessioned2023-10-10T12:49:37Z
dc.date.available2023-10-10T12:49:37Z
dc.date.issued2023
dc.identifier.citationRahmani M., Moghadasi A. N., Shahi S., Eskandarieh S., Azizi H., Hasanzadeh A., Ahmadzade A., Dehnavi A. Z., Farahani R. H., Aminianfar M., et al., "COVID-19 and its implications on the clinico-radiological course of multiple sclerosis: A case-control study", MEDICINA CLINICA, cilt.160, sa.5, ss.187-192, 2023
dc.identifier.issn0025-7753
dc.identifier.othervv_1032021
dc.identifier.otherav_26dbdab8-85e9-40e3-98e6-fa9bdfd2688b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190282
dc.identifier.urihttps://doi.org/10.1016/j.medcli.2022.06.020
dc.description.abstractBackground: Multiple sclerosis (MS) is an immune-mediated disease that has been related to several risk factors such as various viral infections. We carried out this study in order to establish a relationship between COVID-19 infection and MS severity.Methods: In a case-control study, we recruited patients with relapsing-remitting multiple sclerosis (RRMS). Patients were divided into two groups based on positive COVID-19 PCR at the end of the enroll-ment phase. Each patient was prospectively followed for 12 months. Demographical, clinical, and past medical history were collected during routine clinical practice. Assessments were performed every six months; MRI was performed at enrollment and 12 months later.Results: Three hundred and sixty-two patients participated in this study. MS patients with COVID-19 infection had significantly higher increases in the number of MRI lesions (p: 0.019, OR(CI): 6.37(1.54-26.34)) and EDSS scores (p: 0.017), but no difference was found in total annual relapses or relapse rates. COVID-19 infections were positively correlated with EDSS progression (p: 0.02) and the number of new MRI lesions (p: 0.004) and predicted the likelihood of the number of new MRI lesions by an odds of 5.92 (p: 0.018).Conclusion: COVID-19 may lead to higher disability scores in the RRMS population and is associated with developing new Gd-enhancing lesions in MRI imaging. However, no difference was observed between the groups regarding the number of relapses during follow-up.(c) 2022 Elsevier Espana, S.L.U. All rights reserved.
dc.language.isoeng
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectTemel Tıp Bilimleri
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.titleCOVID-19 and its implications on the clinico-radiological course of multiple sclerosis: A case-control study
dc.typeMakale
dc.relation.journalMEDICINA CLINICA
dc.contributor.departmentAJA Univ Med Sci , ,
dc.identifier.volume160
dc.identifier.issue5
dc.identifier.startpage187
dc.identifier.endpage192
dc.contributor.firstauthorID4551612


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