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dc.contributor.authorSinani, Genada
dc.contributor.authorUlker, Zeynep
dc.contributor.authorEroğlu, Cemre
dc.date.accessioned2023-10-10T12:49:49Z
dc.date.available2023-10-10T12:49:49Z
dc.date.issued2023
dc.identifier.citationEroğlu C., Sinani G., Ulker Z., "Current State of Lipid Nanoparticles (SLN and NLC) for Skin Applications", Current pharmaceutical design, cilt.29, sa.21, ss.1632-1644, 2023
dc.identifier.issn1873-4286
dc.identifier.otherav_270b753b-92d8-4235-aa69-a23ba8306519
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190287
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85169174625&origin=inward
dc.identifier.urihttps://doi.org/10.2174/1381612829666230803111120
dc.description.abstractThe increasing knowledge on skin physiology, formulation science and nanotechnology has led to continuous improvements in cosmetics, and introduction of dermocosmetics has been increasing particularly for the management of skin disorders such as acne, eczema, psoriasis, etc. Nowadays, research has been focused on the development of products which can efficiently administer active compounds to the target skin layers while minimizing side effects. The use of multifunctional lipid nanoparticles for cosmetic and dermocosmetic purposes is promising not only because biocompatible ingredients are used in their composition, but also because of their ability to show enhanced skin penetration. Although the introduction of liposomes has been a hallmark of lipid nanoparticles, development of novel systems capable of encapsulating active compounds with tunable release profiles, that show good stability, are easy to manufacture and handle remains a necessity. Solid lipid nanoparticles (SLN) were introduced as alternative formulations for emulsions, liposomes and polymeric nanoparticles, whereas nanostructured lipid carriers (NLC) were developed later as second-generation nanoparticles. However, both SLN and NLC show many inherited advantageous properties to be used for dermal applications including ability to provide occlusion and photoprotective effect and skin hydration, and various SLN and NLC based products are already in the market. This review provides an overview on the current state-of-art of SLN and NLC particularly for cosmetic and dermocosmetic purposes, discuss their formulation composition, structures and preparation techniques. Their use for the topical delivery of active compounds in different skin disorders is highlighted along with examples of commercialized products.
dc.language.isoeng
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectFarmakoloji
dc.subjectİlaç Keşfi
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleCurrent State of Lipid Nanoparticles (SLN and NLC) for Skin Applications
dc.typeMakale
dc.relation.journalCurrent pharmaceutical design
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume29
dc.identifier.issue21
dc.identifier.startpage1632
dc.identifier.endpage1644
dc.contributor.firstauthorID4551566


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