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dc.contributor.authorÖZTÜRK CİVELEK, DİLEK
dc.contributor.authorOKYAR, Alper
dc.contributor.authorAKYEL, Yasemin Kübra
dc.contributor.authorKALELİ DURMAN, Deniz
dc.contributor.authorCİVELEK, Erkan
dc.date.accessioned2023-10-10T13:02:34Z
dc.date.available2023-10-10T13:02:34Z
dc.date.issued2023
dc.identifier.citationCİVELEK E., ÖZTÜRK CİVELEK D., AKYEL Y. K., KALELİ DURMAN D., OKYAR A., "Circadian Dysfunction in Adipose Tissue: Chronotherapy in Metabolic Diseases", Biology, cilt.12, sa.8, 2023
dc.identifier.issn2079-7737
dc.identifier.otherav_2ac8a849-684f-4689-b9ce-8d1d7850c94e
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190395
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/2ac8a849-684f-4689-b9ce-8d1d7850c94e/file
dc.identifier.urihttps://doi.org/10.3390/biology12081077
dc.description.abstractEssential for survival and reproduction, the circadian timing system (CTS) regulates adaptation to cyclical changes such as the light/dark cycle, temperature change, and food availability. The regulation of energy homeostasis possesses rhythmic properties that correspond to constantly fluctuating needs for energy production and consumption. Adipose tissue is mainly responsible for energy storage and, thus, operates as one of the principal components of energy homeostasis regulation. In accordance with its roles in energy homeostasis, alterations in adipose tissue’s physiological processes are associated with numerous pathologies, such as obesity and type 2 diabetes. These alterations also include changes in circadian rhythm. In the current review, we aim to summarize the current knowledge regarding the circadian rhythmicity of adipogenesis, lipolysis, adipokine secretion, browning, and non-shivering thermogenesis in adipose tissue and to evaluate possible links between those alterations and metabolic diseases. Based on this evaluation, potential therapeutic approaches, as well as clock genes as potential therapeutic targets, are also discussed in the context of chronotherapy.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectGenel İmmünoloji ve Mikrobiyoloji
dc.subjectGenel Tarım ve Biyoloji Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectZİRAAT MÜHENDİSLİĞİ
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectİmmünoloji
dc.subjectTarım Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.titleCircadian Dysfunction in Adipose Tissue: Chronotherapy in Metabolic Diseases
dc.typeMakale
dc.relation.journalBiology
dc.contributor.departmentİstanbul Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü
dc.identifier.volume12
dc.identifier.issue8
dc.contributor.firstauthorID4548771


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