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Biological Activities of the Natural Coumarins from Apiaceae Plants

dc.contributor.authorMihoglugil, Feyyaz
dc.contributor.authorAkalgan, Demet
dc.contributor.authorMiski, Mahmud
dc.contributor.authorTosun, Fatma
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorKaradağ, Ayşe Esra
dc.date.accessioned2023-10-10T13:04:36Z
dc.date.available2023-10-10T13:04:36Z
dc.identifier.citationTosun F., Biltekin S. N., Karadağ A. E., Mihoglugil F., Akalgan D., Miski M., "Biological Activities of the Natural Coumarins from Apiaceae Plants", RECORDS OF NATURAL PRODUCTS, 2023
dc.identifier.issn1307-6167
dc.identifier.othervv_1032021
dc.identifier.otherav_2b6e2ba1-0095-44a6-bb73-95a3a5c7a3ea
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190418
dc.identifier.urihttps://doi.org/10.6135/rnp.396.2304.2758
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/2b6e2ba1-0095-44a6-bb73-95a3a5c7a3ea/file
dc.description.abstractNineteen natural coumarins; badrakemin (1), colladonin (2), 14'-acetoxybadrakemin (3), anatolicin (4), 14'-hydroxycolladonin (5), badrakemone (6), karatavicinol (7), 14'-acetoxybadrakemone (8), 14'-acetoxycolladonin (9), colladonin acetate (10), deltoin (11), smyrnioridin (12), isoimperatorin (13), oxypeucedanin (14), bergapten (15), osthol (16), 4'-senecioyloxyostol (17), neopapillarine (18), and scoparone (19) were tested against U87MG, A549, and PC3 cancer cell lines as well as against healthy human embryonic kidney cell line, HEK293. Colladonin (2) was found to have IC50 values of 12.6 and 11.58 & mu;M in A549 and PC3 cell lines, respectively. Deltoin (11) and 14'-acetoxybadrakemin (3) were found to have an IC50 value of 9.92 & mu;M and 11.85 & mu;M against the U87MG cell line, respectively. Remarkably, these compounds show very low cytotoxicity against the healthy human embryonic kidney cell line, HEK293. In addition to the cytotoxic activity, nineteen natural coumarins were tested for their inhibitory activity against 5-LOX, collagenase, and elastase enzymes.
dc.language.isoeng
dc.subjectDiğer
dc.subjectTemel Bilimler
dc.subjectKüçük hayvanlar
dc.subjectFarmakoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectProses Kimyası ve Teknolojisi
dc.subjectBİTKİ BİLİMLERİ
dc.subjectFizik Bilimleri
dc.subjectBitki Bilimi
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectKİMYA, UYGULAMALI
dc.subjectKimya
dc.subjectTemel Bilimler (SCI)
dc.subjectKİMYA, TIBBİ
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectSağlık Bilimleri
dc.titleBiological Activities of the Natural Coumarins from Apiaceae Plants
dc.typeMakale
dc.relation.journalRECORDS OF NATURAL PRODUCTS
dc.contributor.departmentİstanbul Medipol Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü
dc.contributor.firstauthorID4561219


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