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dc.contributor.authorOzpinar, H
dc.contributor.authorDrochner, W
dc.contributor.authorAugonyte, G
dc.date.accessioned2021-03-03T07:54:29Z
dc.date.available2021-03-03T07:54:29Z
dc.date.issued1999
dc.identifier.citationOzpinar H., Augonyte G., Drochner W., "Inactivation of ochratoxin in ruminal fluid with variation of pH-value and fermentation parameters in an in vitro system", ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.7, sa.1, ss.1-9, 1999
dc.identifier.issn1382-6689
dc.identifier.otherav_148c584b-e458-4897-82b8-3829aee0de04
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/19200
dc.identifier.urihttps://doi.org/10.1016/s1382-6689(98)00041-6
dc.description.abstractOchratoxin A which is degraded to ochratoxin a in the rumen may have negative effects on kidney function. However, the toxicity of ochratoxin a is significantly lower than of ochratoxin A. The objective of this study was to examine the effect of different ruminal parameters such as pH and fermentation on the inactivation of ochratoxin A. These studies were performed under in-vitro conditions by using the 'Hohenheimer gas test'. Incubation was carried out over a period of 48 h by incubating pure ochratoxin A with a mixture of ruminal fluid and a culture medium. The concentration of ochratoxin A was 200 mu g/l of ruminal fluid. Ochratoxine was determined by high performance liquid chromatography (HPLC)-fluorescence detection. The recovery rates for ochratoxin A and ochratoxin alpha were 70 +/- 6 and 53 +/- 4%, respectively. The ruminal degration rate of these toxins was affected by the relation of roughage and concentrate in the complete diet, i.e. in diets comprising of 40% roughage and 60% of concentrate the degradation rate was higher than in diets consisting of 100% concentrate. The relation of roughage to concentrate in the complete diets (n = 4) had a significant effect on the half-life of the toxin that were measured. In this study, a shorter half-life for ochratoxin A was estimated when starch was added to the medium, pH had no significant effect on the degradation rate of ochratoxin A. (C) 1999 Elsevier Science B.V. All rights reserved.
dc.language.isoeng
dc.subjectFarmasötik Toksikoloji
dc.subjectÇEVRE BİLİMLERİ
dc.subjectÇevre / Ekoloji
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTarımsal Bilimler
dc.subjectÇevre Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTOKSİKOLOJİ
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectMeslek Bilimleri
dc.titleInactivation of ochratoxin in ruminal fluid with variation of pH-value and fermentation parameters in an in vitro system
dc.typeMakale
dc.relation.journalENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
dc.contributor.department, ,
dc.identifier.volume7
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.endpage9
dc.contributor.firstauthorID122959


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