dc.contributor.author | Buyukunal, E. | |
dc.contributor.author | Ozguroglu, M. | |
dc.contributor.author | Turna, H. | |
dc.contributor.author | Serdengecti, S. | |
dc.contributor.author | Demirelli, FUAT HULUSİ | |
dc.contributor.author | Öztürk, Turgut | |
dc.contributor.author | Ilvan, S. | |
dc.contributor.author | Tural, D. | |
dc.date.accessioned | 2021-03-03T07:54:54Z | |
dc.date.available | 2021-03-03T07:54:54Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Tural D., Serdengecti S., Demirelli F. H. , Öztürk T., Ilvan S., Turna H., Ozguroglu M., Buyukunal E., "Clinical significance of p95HER2 overexpression, PTEN loss and PI3K expression in p185HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies", BRITISH JOURNAL OF CANCER, cilt.110, sa.8, ss.1968-1976, 2014 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_14968ab4-fa0a-48dc-85f6-ee04cf699cc4 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/19231 | |
dc.identifier.uri | https://doi.org/10.1038/bjc.2014.72 | |
dc.description.abstract | Background: Overexpression of p185HER2 is an established poor prognostic factor in breast cancer, portending an aggressive course and potential for early metastasis. On the other hand, monoclonal antibody trastuzumab is widely used in the clinic to target this overexpressed oncogene. Unfortunately, similar to 30-40% of all patients overexpressing HER2 respond to trastuzumab, warranting further research regarding the structure and additional modulation of the receptor. In this study, we aimed to investigate the response to trastuzumab in terms of the potential roles of several oncogenic pathways (phosphatase and tensin homologue (PTEN) and phosphatidylinositol 3-kinase (PI3K)) and a truncated receptor protein, p95HER2, retrospectively. | |
dc.language.iso | eng | |
dc.subject | İç Hastalıkları | |
dc.subject | Onkoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | Clinical significance of p95HER2 overexpression, PTEN loss and PI3K expression in p185HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies | |
dc.type | Makale | |
dc.relation.journal | BRITISH JOURNAL OF CANCER | |
dc.contributor.department | İstanbul Teknik Üniversitesi , İnşaat , İnşaat Mühendisliği | |
dc.identifier.volume | 110 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 1968 | |
dc.identifier.endpage | 1976 | |
dc.contributor.firstauthorID | 14515 | |