dc.contributor.author | Bulut, Turker | |
dc.contributor.author | Cacina, Canan | |
dc.contributor.author | Balik, Emre | |
dc.contributor.author | Gulluoglu, Mine | |
dc.contributor.author | Agachan, Bedia | |
dc.contributor.author | Canbay, Emel | |
dc.contributor.author | Isbir, Turgay | |
dc.contributor.author | Bugra, Dursun | |
dc.contributor.author | Yamaner, Sumer | |
dc.contributor.author | Eraltan, Ilhan Yaylim | |
dc.contributor.author | Yilmaz, Aytul | |
dc.date.accessioned | 2021-03-03T08:03:40Z | |
dc.date.available | 2021-03-03T08:03:40Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Canbay E., Agachan B., Gulluoglu M., Isbir T., Balik E., Yamaner S., Bulut T., Cacina C., Eraltan I. Y. , Yilmaz A., et al., "Possible Associations of APE1 Polymorphism with Susceptibility and HOGG1 Polymorphism with Prognosis in Gastric Cancer", ANTICANCER RESEARCH, cilt.30, sa.4, ss.1359-1364, 2010 | |
dc.identifier.issn | 0250-7005 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_157ab80e-2aed-4543-8d70-91b9ab85e1d6 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/19797 | |
dc.description.abstract | Background: Multiple genetic and epigenetic alterations in several genes are implicated in the multistep process of human gastric carcinogenesis. In this study, we examined the polymorphisms of six DNA repair genes: APE1, HOGG1, XRCC1, XRCC3, XPD, and XPG in patients with gastric cancer (GC). Patients and Methods: Forty patients with GC and 247 controls were included in this study. DNA polymorphisms were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. Results: The frequency of the Asp/Glu genotype and Glu allele of APE1 in patients with GC was significantly higher than in the control group (p=0.05). We also observed a higher frequency of the Ser/Ser genotype of HOGG1 in grade III tumors, and in tumors with metastasis to adjacent tissue and solid organs (p<0.05). Conclusion: Our results suggest that (i) APE1 gene polymorphism may be associated with GC risk and (ii) HOGG1 gene polymorphism may be informative in the prognosis of GC. | |
dc.language.iso | eng | |
dc.subject | Onkoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | Possible Associations of APE1 Polymorphism with Susceptibility and HOGG1 Polymorphism with Prognosis in Gastric Cancer | |
dc.type | Makale | |
dc.relation.journal | ANTICANCER RESEARCH | |
dc.contributor.department | Basaksehir State Hospital , , | |
dc.identifier.volume | 30 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 1359 | |
dc.identifier.endpage | 1364 | |
dc.contributor.firstauthorID | 28031 | |