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dc.contributor.authorAhishali, Bülent
dc.contributor.authorKaya, Mehmet
dc.contributor.authorElmas, Imdat
dc.contributor.authorArican, Nadir
dc.contributor.authorkalaycı, RİVAZE
dc.contributor.authorKucuk, Mutlu
dc.date.accessioned2021-03-03T08:11:42Z
dc.date.available2021-03-03T08:11:42Z
dc.date.issued2006
dc.identifier.citationkalaycı R., Kaya M., Ahishali B., Arican N., Elmas I., Kucuk M., "Long-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats", LIFE SCIENCES, cilt.79, sa.1, ss.16-20, 2006
dc.identifier.issn0024-3205
dc.identifier.otherav_16374e16-3613-4f26-af0c-749cd1d820a0
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/20291
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2005.12.034
dc.description.abstractWe investigated whether the severity of blood-brain barrier disruption caused by pentylenetetrazole-induced seizures is modified by long-term nitric oxide synthase inhibition in rats. Rats were given N-omega-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, in drinking water for 4 weeks, and then treated with pentylenetetrazole to induce seizures. Damage to the blood-brain barrier was investigated using Evans blue dye extravasation. Serum nitric oxide concentration was decreased in L-NAME-treated rats (P < 0.01). L-NAME and/or pentylenetetrazole treatments elevated systolic blood pressure of animals (P < 0.01). L-NAME caused an increase in the mortality rate after pentylenetetrazole injection leading to the death of animals at about 15 min after the onset of the seizure. Pentylenetetrazole-induced seizures in rats treated with L-NAME caused a significant increase in Evans blue dye extravasation into cerebral cortex, diencephalon and cerebellum, as compared with seizures evoked by pentylenetetrazole injection to L-NAME-untreated rats (P < 0.01). Data presented here suggest that the degree of blood-brain barrier disruption induced by seizures is more pronounced in long-term nitric oxide deficiency. (c) 2005 Elsevier Inc. All rights reserved.
dc.language.isoeng
dc.subjectTıp
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleLong-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats
dc.typeMakale
dc.relation.journalLIFE SCIENCES
dc.contributor.departmentİstanbul Üniversitesi , Deneysel Tıp Araştırma Enstitüsü , Laboratuvar Hayvanları Bilimi Anabilim Dalı
dc.identifier.volume79
dc.identifier.issue1
dc.identifier.startpage16
dc.identifier.endpage20
dc.contributor.firstauthorID5542


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