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Heme oxygenase induction protects liver against oxidative stress in X-irradiated aged rats

dc.contributor.authorÖztezcan, Serdar
dc.contributor.authorKırgız, Banu
dc.contributor.authorDogru-Abbasoglu, Semra
dc.contributor.authorUnlucerci, Yaşar Meryem Yeşim
dc.contributor.authorBilge, Hatice Bilge
dc.contributor.authorUysal, Mehmet Müjdat
dc.contributor.authorAykaç-Toker, Gülçin
dc.date.accessioned2021-03-03T08:18:13Z
dc.date.available2021-03-03T08:18:13Z
dc.date.issued2004
dc.identifier.citationÖztezcan S., Kırgız B., Unlucerci Y. M. Y. , Dogru-Abbasoglu S., Bilge H. B. , Uysal M. M. , Aykaç-Toker G., "Heme oxygenase induction protects liver against oxidative stress in X-irradiated aged rats", BIOGERONTOLOGY, cilt.5, sa.2, ss.99-105, 2004
dc.identifier.issn1389-5729
dc.identifier.othervv_1032021
dc.identifier.otherav_16c95e58-d89b-463d-b37a-851ec9bddb01
dc.identifier.urihttp://hdl.handle.net/20.500.12627/20646
dc.identifier.urihttps://doi.org/10.1023/b:bgen.0000025073.46100.01
dc.description.abstractWe studied the effect of total body X-ray irradiation on the heme oxygenase-1 (HO-1) induction in the livers of young and aged rats. For this purpose, male rats were irradiated with a dose of 17 Gy. The animals were killed 5 h after irradiation. HO-1 protein expression was found to be increased two fold in aged rat liver, but lipid peroxide levels had decreased significantly where no change was observed either in inducible nitric oxide synthase protein expression or in glutathione levels. Contradictory results with respect to HO-1 and lipid peroxidation levels were obtained in the livers of young animals. These results suggest that the additional oxidative stress produced in irradiated rats may be compensated by HO-1 induction as decreased lipid peroxide levels were shown in the livers of aged animals.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGeriatri
dc.subjectGERİATRİK VE GERONTOLOJİ
dc.subjectKlinik Tıp
dc.titleHeme oxygenase induction protects liver against oxidative stress in X-irradiated aged rats
dc.typeMakale
dc.relation.journalBIOGERONTOLOGY
dc.contributor.departmentYeditepe Üniversitesi , ,
dc.identifier.volume5
dc.identifier.issue2
dc.identifier.startpage99
dc.identifier.endpage105
dc.contributor.firstauthorID40424


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