dc.contributor.author | Borekci, Şermin | |
dc.contributor.author | GEMİCİOĞLU, Bilun | |
dc.contributor.author | Doventas, Yasemin Erdogan | |
dc.contributor.author | Koldas, Macit | |
dc.contributor.author | Uzan, Gulfidan Cakmak | |
dc.date.accessioned | 2021-03-02T16:01:59Z | |
dc.date.available | 2021-03-02T16:01:59Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Uzan G. C. , Borekci Ş., Doventas Y. E. , Koldas M., GEMİCİOĞLU B., "The relationship between inflammatory markers and spirometric parameters in ACOS, Asthma, and COPD", JOURNAL OF ASTHMA, cilt.57, sa.12, ss.1273-1279, 2020 | |
dc.identifier.issn | 0277-0903 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_5be11fc8-c424-405f-89f7-81777c329f85 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/2117 | |
dc.identifier.uri | https://doi.org/10.1080/02770903.2019.1652644 | |
dc.description.abstract | Objective: The inflammatory mechanisms underpinning asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) have not been fully elucidated. Here, we examined the levels of cysteinyl leukotrienes (cys-LTs), prostaglandin D2 (PG-D2), prostaglandin E2 (PG-E2), interleukin 5 (IL-5), and a disintegrin and metalloprotease domain (ADAM 33) in ACOS patients to determine the relationship between levels of these inflammatory markers and pulmonary functions. Methods: Blood samples were obtained from asthma, COPD, and ACOS patients who received combined therapy and were stable for the last month to measure cys-LTs, PG-D2, PG-E2, IL-5, and ADAM33 levels. Differences between groups and their correlations with pulmonary function tests were evaluated. Results: In total, 24 ACOS, 27 asthma, and 35 COPD patients were included. . PG-D2 levels were higher in ACOS (120.9 +/- 117.2 ng/L) and asthma (119.6 +/- 111.7 ng/L) patients than in COPD (82.6 +/- 46.7 ng/L) patients (p = 0.036 and p = 0.038, respectively). In ACOS patients, PG-D2, cys-LTs, and ADAM33 levels were negatively correlated with FEV1/FVC% values (p = 0.021, p = 0.008, and p = 0.028, respectively). In COPD patients, a negative correlation was detected between PG-E2 and FEV1/FVC% (p = 0.007), whereas positive correlations were detected between IL-5 and pulmonary function tests, including FVC, FVC%, FEV1, FEV1%, FEF25-75, and FEF25-75% (p = 0.047, p = 0.005, p = 0.002, p = 0.002, p = 0.010, and p = 0.005, respectively). In asthma patients, cys-LTs levels were negatively correlated with FEV1 and FEF25-75 values (p = 0.045 and p = 0.037, respectively). Conclusions: PG-D2 levels may be a valuable biomarker to differentiate COPD in asthma and ACOS patients. | |
dc.language.iso | eng | |
dc.subject | Respiratory Care | |
dc.subject | Immunology and Allergy | |
dc.subject | Pulmonary and Respiratory Medicine | |
dc.subject | Health Sciences | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Göğüs Hastalıkları ve Allerji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | SOLUNUM SİSTEMİ | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ALERJİ | |
dc.title | The relationship between inflammatory markers and spirometric parameters in ACOS, Asthma, and COPD | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF ASTHMA | |
dc.contributor.department | Istanbul Haseki Training & Research Hospital , , | |
dc.identifier.volume | 57 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1273 | |
dc.identifier.endpage | 1279 | |
dc.contributor.firstauthorID | 2507428 | |