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dc.contributor.authorAkcay, Halil Ibrahim
dc.contributor.authorOge, Ali Emre
dc.contributor.authorTuzun, Erdem
dc.contributor.authorKucukali, Cem İsmail
dc.contributor.authorKurtuncu, Murat
dc.date.accessioned2021-03-03T08:58:00Z
dc.date.available2021-03-03T08:58:00Z
dc.date.issued2015
dc.identifier.citationKucukali C. İ. , Kurtuncu M., Akcay H. I. , Tuzun E., Oge A. E. , "Peripheral nerve hyperexcitability syndromes", REVIEWS IN THE NEUROSCIENCES, cilt.26, sa.2, ss.239-251, 2015
dc.identifier.issn0334-1763
dc.identifier.othervv_1032021
dc.identifier.otherav_1a722322-6871-413c-acc4-38ac11a65919
dc.identifier.urihttp://hdl.handle.net/20.500.12627/23053
dc.identifier.urihttps://doi.org/10.1515/revneuro-2014-0066
dc.description.abstractPeripheral nerve hyperexcitability (PNH) syndromes can be subclassified as primary and secondary. The main primary PNH syndromes are neuromyotonia, cramp-fasciculation syndrome (CFS), and Morvan's syndrome, which cause widespread symptoms and signs without the association of an evident peripheral nerve disease. Their major symptoms are muscle twitching and stiffness, which differ only in severity between neuromyotonia and CFS. Cramps, pseudomyotonia, hyperhidrosis, and some other autonomic abnormalities, as well as mild positive sensory phenomena, can be seen in several patients. Symptoms reflecting the involvement of the central nervous system occur in Morvan's syndrome. Secondary PNH syndromes are generally seen in patients with focal or diffuse diseases affecting the peripheral nervous system. The PNH-related symptoms and signs are generally found incidentally during clinical or electrodiagnostic examinations. The electrophysiological findings that are very useful in the diagnosis of PNH are myokymic and neuromyotonic discharges in needle electromyography along with some additional indicators of increased nerve fiber excitability. Based on clinicopathological and etiological associations, PNH syndromes can also be classified as immune mediated, genetic, and those caused by other miscellaneous factors. There has been an increasing awareness on the role of voltage-gated potassium channel complex autoimmunity in primary PNH pathogenesis. Then again, a long list of toxic compounds and genetic factors has also been implicated in development of PNH. The management of primary PNH syndromes comprises symptomatic treatment with anticonvulsant drugs, immune modulation if necessary, and treatment of possible associated dysimmune and/or malignant conditions.
dc.language.isoeng
dc.subjectSinirbilim ve Davranış
dc.subjectNEUROSCIENCES
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.titlePeripheral nerve hyperexcitability syndromes
dc.typeMakale
dc.relation.journalREVIEWS IN THE NEUROSCIENCES
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume26
dc.identifier.issue2
dc.identifier.startpage239
dc.identifier.endpage251
dc.contributor.firstauthorID38521


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