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dc.contributor.authorAydogmus, Z.
dc.contributor.authorAboul-Enein, H. Y.
dc.contributor.authorYilmaz, E. M.
dc.date.accessioned2021-03-03T09:06:41Z
dc.date.available2021-03-03T09:06:41Z
dc.identifier.citationYilmaz E. M. , Aydogmus Z., Aboul-Enein H. Y. , "Determination of Nilotinib in Spiked Plasma, Urine, and Capsules by High-Performance Liquid Chromatography with Fluorimetric Detection", ACTA CHROMATOGRAPHICA, cilt.28, ss.313-331, 2016
dc.identifier.issn1233-2356
dc.identifier.othervv_1032021
dc.identifier.otherav_1b402c65-974c-4f5e-b7c9-4eea77f6a13f
dc.identifier.urihttp://hdl.handle.net/20.500.12627/23596
dc.identifier.urihttps://doi.org/10.1556/1326.2016.28.3.3
dc.description.abstractA precise and sensitive reversed phase high-performance thin-layer chromatography (RP-HPLC) method was developed for the determination of nilotinib (NTB) in spiked plasma, urine, and pharmaceutical capsule formulation. The method was based on derivatization NTB with 4-chloro-7-nitrobenzofurazan (NBD-Cl) in the borax buffer (pH 9). The method employs an isocratic elution using acetonitrile and 10 mM orthophosphoric acid (40: 60 v/v) as a mobile phase and an C-18 column (4.6 mm x 250 mm, 5 mu m, Waters Symmetry), with a fluorescence detector (lambda(ex): 447 nm, lambda(em): 530 nm). The method validation was performed with respect to linearity, recovery, accuracy, precision, and stability. The linear ranges were 100-600 ng mL(-1) in standard solution, plasma, and urine. Correlation coefficients (r(2)) were higher than 0.9997 for all of the analytes, indicating good linear relationship. The percentage recovery was 87.89% for plasma, 95.35% for urine, and 96.07% for capsules.
dc.language.isoeng
dc.subjectKİMYA, ANALİTİK
dc.subjectTemel Bilimler
dc.subjectAnalitik Kimya
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.titleDetermination of Nilotinib in Spiked Plasma, Urine, and Capsules by High-Performance Liquid Chromatography with Fluorimetric Detection
dc.typeMakale
dc.relation.journalACTA CHROMATOGRAPHICA
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume28
dc.identifier.startpage313
dc.identifier.endpage331
dc.contributor.firstauthorID2360145


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