Overexpression of FUS and PRDX5 Genes In Multiple Myeloma Patients

Abstract

Objective: Multiple myeloma is a hematopoietic malignancy characterized by the clonal proliferation of plasma cells. Weevaluated our previous RNA-sequencing project’s (Project ID:7348) data of the gene expression profiles of bone marrowmyeloma cells in multiple myeloma patients.Materials-Methods: Assessment of data from the aforementioned study revealed that the PTPN6, FUS, CD74, MS4A3, PRDX5and UNC45B genes were found to be expressed at significantly different levels compared to control samples. These genes areassociated with certain pathways such as signal transduction, immunological system and cellular response. In the present studywe aimed to confirm the expression levels of these genes in patients with multiple myeloma (n=50) by the qRT-PCR technique.Results: No statistically significant difference was found in the PTPN6, CD74, MS4A3 and UNC45B genes between the patientgroup (n=50) and the control group (n=16). However, FUS and PRDX5 gene expressions were significantly higher in the patientgroup than the control group.Conclusion: Considering the functions of FUS and PRDX5 genes and their importance in cancer, it is thought that these genesmay shed light on new treatment options for multiple myeloma.This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University (Project ID:24651).Keywords: Multiple Myeloma, Pathway and Expression Analysis