Basit öğe kaydını göster

dc.contributor.authorAydogan, Aysen
dc.contributor.authorGulluoglu, Mine
dc.contributor.authorGokce, Selim
dc.contributor.authorCeltik, Coskun
dc.contributor.authorDurmaz, Ozlem
dc.contributor.authorSokucu, Semra
dc.date.accessioned2021-03-03T09:56:35Z
dc.date.available2021-03-03T09:56:35Z
dc.date.issued2010
dc.identifier.citationSokucu S., Gokce S., Gulluoglu M., Aydogan A., Celtik C., Durmaz O., "The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naive chronic hepatitis B infection", SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, cilt.42, sa.9, ss.699-703, 2010
dc.identifier.issn0036-5548
dc.identifier.otherav_1fbae4e6-f7b7-4132-91e1-51c9c7d87991
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/26430
dc.identifier.urihttps://doi.org/10.3109/00365541003774616
dc.description.abstractThe aim of this study was to investigate whether the non-invasive serum marker FibroTest-ActiTest (FT-AT) reliably predicts the histological stage of fibrosis and/or activity, and decreases the need for a liver biopsy. Twenty-five children with naive chronic hepatitis B were analyzed for haptoglobin, alpha 2-macroglobulin, apolipoprotein A1, bilirubin, gamma-glutamyl transferase, and alanine aminotransferase activity, and the FT-AT scores were computed. FT-AT scores were compared with histological data. FT predicted insignificant fibrosis in 14/23 (61%) patients at a cut-off level of 0.31. Nine patients (36%) had significant histological fibrosis, but none were predicted by FT. There was no correlation between FT scores and histological stage of fibrosis (r: -0.221, p = 0.228). All 4 patients with significant histological activity had corresponding significant activity in AT (100%). Fifteen out of the 19 patients (78.9%) with significant activity in AT had insignificant histological activity. At the cut-off level of 0.36, AT predicted insignificant activity in all 6 patients (100%). There was no correlation between AT scores and histological activity (r: 0.245, p = 0.237). According to histological data, 12 patients were candidates for treatment, but FT-AT did not predict 3 of them (25%). FT-AT does not appear ready for use in detecting either the stage of fibrosis or activity in children with chronic hepatitis B.
dc.language.isoeng
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTemel Bilimler
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri
dc.titleThe role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naive chronic hepatitis B infection
dc.typeMakale
dc.relation.journalSCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume42
dc.identifier.issue9
dc.identifier.startpage699
dc.identifier.endpage703
dc.contributor.firstauthorID56706


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster