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Determination of acamprosate in human plasma by UPLC-MS/MS: Application to therapeutic drug monitoring

dc.contributor.authorOzilhan, Selma
dc.contributor.authorSağırlı, Ahmet Olcay
dc.contributor.authorKul, Aykut
dc.contributor.authorOzdemir, Murat
dc.date.accessioned2021-03-02T16:15:13Z
dc.date.available2021-03-02T16:15:13Z
dc.date.issued2020
dc.identifier.citationOzdemir M., Kul A., Ozilhan S., Sağırlı A. O. , "Determination of acamprosate in human plasma by UPLC-MS/MS: Application to therapeutic drug monitoring", BIOMEDICAL CHROMATOGRAPHY, cilt.34, sa.11, 2020
dc.identifier.issn0269-3879
dc.identifier.otherav_62379920-1580-4e15-8ca1-e8b847f9caa2
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/2647
dc.identifier.urihttps://doi.org/10.1002/bmc.4936
dc.description.abstractAcamprosate is a medication used to treat alcohol dependence. Therapeutic drug monitoring is important in drugs for the treatment of substance-related disorders. Therefore, in this study, a new selective, very simple and rapid ultra-performance liquid chromatography-tandem mass spectrometer method was developed for the therapeutic drug monitoring of acamprosate. The developed method allows the determination of acamprosate in human plasma. The method was validated in terms of selectivity and linearity, which was in the range of 100-1,200 ng/ml for acamprosate. Intra-assay and inter-assay accuracy and precision were within the acceptable limits of the Eueopean Medicines Agency guideline. The lower limit of quantitation was 100 ng/ml for acamprosate. The developed method was successfully applied for therapeutic drug monitoring in patient plasma samples.
dc.language.isoeng
dc.subjectPharmacy
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectBİYOKİMYASAL ARAŞTIRMA YÖNTEMLERİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectAnalytical Chemistry
dc.subjectFiltration and Separation
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPharmacology (medical)
dc.subjectBiochemistry (medical)
dc.subjectDrug Guides
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectKİMYA, ANALİTİK
dc.subjectKimya
dc.subjectTemel Bilimler (SCI)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectAnalitik Kimya
dc.subjectTemel Bilimler
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectPharmacology
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.titleDetermination of acamprosate in human plasma by UPLC-MS/MS: Application to therapeutic drug monitoring
dc.typeMakale
dc.relation.journalBIOMEDICAL CHROMATOGRAPHY
dc.contributor.departmentÜsküdar Üniversitesi , ,
dc.identifier.volume34
dc.identifier.issue11
dc.contributor.firstauthorID2198667


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