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dc.contributor.authorYalcinkaya, Nazli
dc.contributor.authorHoffmann, Carolin
dc.contributor.authorStevens, Jo
dc.contributor.authorZong, Shenghua
dc.contributor.authorvan Kruining, Daan
dc.contributor.authorSaxena, Abhishek
dc.contributor.authorDe Hert, Marc
dc.contributor.authorGonzalez-Vioque, Emiliano
dc.contributor.authorArango, Celso
dc.contributor.authorLindstrom, Jon
dc.contributor.authorDe Beets, Marc H.
dc.contributor.authorRutter, Bail P. F.
dc.contributor.authorvan Os, Jim
dc.contributor.authorMolenaar, Peter
dc.contributor.authorLosen, Mario
dc.contributor.authorMartinez-Martinez, Pilar
dc.contributor.authorTuzun, Erdem
dc.contributor.authorKucukali, Cem Ismail
dc.date.accessioned2021-03-03T10:31:36Z
dc.date.available2021-03-03T10:31:36Z
dc.date.issued2018
dc.identifier.citationHoffmann C., Stevens J., Zong S., van Kruining D., Saxena A., Kucukali C. I. , Tuzun E., Yalcinkaya N., De Hert M., Gonzalez-Vioque E., et al., "Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder", PLOS ONE, cilt.13, sa.12, 2018
dc.identifier.issn1932-6203
dc.identifier.otherav_23146e64-d1a3-406a-8c69-576bb16958e1
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/28571
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0208412
dc.description.abstractThe alpha 7 acetylcholine receptor (AChR) has been linked with the onset of psychotic symptoms and we hypothesized therefore that it might also be an autoimmune target. Here, we describe a new radioimmunoassay (RIA) using iodine 125-labelled alpha-bungarotoxin and membrane extract from transfected HEK293 cells expressing human alpha 7 AChR. This RIA was used to analyze sera pertaining to a cohort of 711 subjects, comprising 368 patients diagnosed with schizophrenia spectrum disorders, 140 with bipolar disorder, 58 individuals diagnosed of other mental disorders, and 118 healthy comparison subjects. We identified one patient whose serum tested positive although with very low levels (0.2 nM) for alpha 7 AChR-specific antibodies by RIA. Three out of 711 sera contained antibodies against iodine 125-labelled alpha-bungarotoxin, because they precipitated with it in the absence of alpha 7 AChR. This first evidence suggests that autoantibodies against alpha 7 AChR are absent or very rare in these clinical groups.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectTemel Bilimler (SCI)
dc.titleAlpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder
dc.typeMakale
dc.relation.journalPLOS ONE
dc.contributor.departmentHogeschool Maastricht , ,
dc.identifier.volume13
dc.identifier.issue12
dc.contributor.firstauthorID259160


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