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dc.contributor.authorReiter, RJ
dc.contributor.authorTamer, S
dc.contributor.authorAkbulut, M
dc.contributor.authorTuzcu, M
dc.contributor.authorBaydas, G
dc.date.accessioned2021-03-03T10:56:01Z
dc.date.available2021-03-03T10:56:01Z
dc.date.issued2005
dc.identifier.citationBaydas G., Reiter R., Akbulut M., Tuzcu M., Tamer S., "Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels", NEUROSCIENCE, cilt.135, sa.3, ss.879-886, 2005
dc.identifier.issn0306-4522
dc.identifier.otherav_256a7450-5d15-4d1e-89dc-af6fb4e76d8a
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/30042
dc.identifier.urihttps://doi.org/10.1016/j.neuroscience.2005.05.048
dc.description.abstractIn the present study, we examined the molecular mechanism by which homocysteine causes neuronal cell apoptosis. We further investigated the mechanisms of melatonin's ability to reduce homocysteine-induced apoptosis. Consistent with its antioxidant properties, melatonin reduced homocysteine-induced lipid peroxidation and stimulated glutathione peroxidase enzyme activity in hippocampus of rats with hyperhomocysteinemia. Furthermore, melatonin treatment diminished cytochrome c release from mitochondria and reduced caspase 3 and caspase 9 activation induced by hyperhomocysteinemia. Chronic hyperhomocysteinemia also led to poly(ADP-ribose) polymerase cleavage and subsequently DNA fragmentation. Treatment with melatonin markedly inhibited poly(ADP-ribose) polymerase cleavage and reduced DNA damage. Hyperhomocysteinemia caused an elevation of pro-apoptotic Bax levels while reducing antiapoptotic protein, Bcl-2, levels. Daily administration of melatonin up-regulated Bcl-2 and down-regulated Bax levels. We propose that, in addition to its antioxidant properties, melatonin has the ability to protect neuronal cells against apoptosis mediated homocysteine neurotoxicity by modulating apoptosis-regulatory proteins in the hippocampus of rats. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTemel Bilimler
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri
dc.titleMelatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels
dc.typeMakale
dc.relation.journalNEUROSCIENCE
dc.contributor.department, ,
dc.identifier.volume135
dc.identifier.issue3
dc.identifier.startpage879
dc.identifier.endpage886
dc.contributor.firstauthorID174173


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