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dc.contributor.authorCatalgol, Betul Karademir
dc.contributor.authorAlpertunga, Buket
dc.contributor.authorOzden, Sibel
dc.date.accessioned2021-03-03T10:59:46Z
dc.date.available2021-03-03T10:59:46Z
dc.date.issued2007
dc.identifier.citationCatalgol B. K. , Ozden S., Alpertunga B., "Effects of trichlorfon on malondialdehyde and antioxidant system in human erythrocytes", TOXICOLOGY IN VITRO, cilt.21, sa.8, ss.1538-1544, 2007
dc.identifier.issn0887-2333
dc.identifier.othervv_1032021
dc.identifier.otherav_25811493-13f2-496a-8220-596f6bc21a29
dc.identifier.urihttp://hdl.handle.net/20.500.12627/30092
dc.identifier.urihttps://doi.org/10.1016/j.tiv.2007.06.002
dc.description.abstractOrganophosphorus insecticides may induce oxidative stress leading to generation of free radicals and alteration in antioxidant system. The aim of this study was to examine the potency of trichlorfon, an organophosphate insecticide, to induce oxidative stress response in human erythrocytes in vitro. For this purpose trichlorfon solutions in different concentrations and erythrocyte solutions were incubated at 37 degrees C for 60 min. At the end of the incubation time, malondialdehyde (NIDA), an end product of lipid peroxidation, total glutathione, reduced glutathione (GSH) levels, activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzymes were determined by spectrophotometric methods. Trichlorfon increased MDA formation depended on the concentration. On the other hand, decreases in the GSH-Px activity, GSH levels and increases in the total glutathione levels, SOD and CAT activities were seen in the studied concentrations. The present findings indicate that the in vitro toxicity of trichlorfon may be associated with oxidative stress. (C) 2007 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTOKSİKOLOJİ
dc.titleEffects of trichlorfon on malondialdehyde and antioxidant system in human erythrocytes
dc.typeMakale
dc.relation.journalTOXICOLOGY IN VITRO
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume21
dc.identifier.issue8
dc.identifier.startpage1538
dc.identifier.endpage1544
dc.contributor.firstauthorID14654


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