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dc.contributor.authorGulsen-Parman, Yesim
dc.contributor.authorToker, Alper
dc.contributor.authorYilmaz, Vuslat
dc.contributor.authorDeymeer, Feza
dc.contributor.authorOflazer-Serdaroglu, Piraye
dc.contributor.authorGungor-Tuncer, Ozlem
dc.contributor.authorSaruhan-Direskeneli, Guher
dc.date.accessioned2021-03-03T11:10:22Z
dc.date.available2021-03-03T11:10:22Z
dc.identifier.citationGungor-Tuncer O., Yilmaz V., Toker A., Saruhan-Direskeneli G., Gulsen-Parman Y., Oflazer-Serdaroglu P., Deymeer F., "Prompt Response to Prednisone Predicts Benign Course in MuSK-MG", EUROPEAN NEUROLOGY, cilt.78, ss.137-142, 2017
dc.identifier.issn0014-3022
dc.identifier.otherav_2661ef28-9195-45ac-8b57-a74f99168d54
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/30691
dc.identifier.urihttps://doi.org/10.1159/000479228
dc.description.abstractBackground: The difficult course of patients with myasthenia gravis (MG) with anti-muscle-specific tyrosine kinase antibodies (MuSK) has been emphasized. However, no clear information is available on patients who have a benign course. Methods: This study was aimed at comparing patients with favorable (minimal manifestations [MM] or better) and unfavorable outcomes to determine whether excellent response to corticosteroid (CS) treatment within 3 months (good response-3 months) has any predictive effect on the prognosis. Results: Forty-six percent of 46 patients had a favorable outcome at year 3 and 54% at final follow-up. The major finding of this study was its high predictive value with good response- 3 months. Those with good response-3 months had significantly more favorable outcome as compared to those without at year 3. The positive predictive value of good response- 3 months was high (89% at year 3 and 84% at final follow-up). The negative predictive value diminished from 85% at year 3 to 67% at final follow-up due to increasing number of patients improving in the long run. Overall, 33% of the patients had a benign course with good response-3 months and no major exacerbations until the end of followup. Conclusions: Excellent response to CSs within 3 months appears to predict a favorable outcome in MuSK-MG. (C) 2017 S. Karger AG, Basel
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectKLİNİK NEUROLOJİ
dc.titlePrompt Response to Prednisone Predicts Benign Course in MuSK-MG
dc.typeMakale
dc.relation.journalEUROPEAN NEUROLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume78
dc.identifier.startpage137
dc.identifier.endpage142
dc.contributor.firstauthorID238203


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