Show simple item record

dc.contributor.authorArkali, N. Burcu
dc.contributor.authorKARADENİZ, Derya
dc.contributor.authorSALTIK, Sema
dc.contributor.authorYALÇINKAYA, Cengiz
dc.contributor.authorBENBİR ŞENEL, Gülçin
dc.date.accessioned2021-03-02T16:31:51Z
dc.date.available2021-03-02T16:31:51Z
dc.date.issued2020
dc.identifier.citationBENBİR ŞENEL G., Arkali N. B. , SALTIK S., YALÇINKAYA C., KARADENİZ D., "The effects of non-invasive mechanical ventilation on cardiac autonomic dysfunction in spinal muscular atrophy", NEUROMUSCULAR DISORDERS, cilt.30, ss.845-850, 2020
dc.identifier.issn0960-8966
dc.identifier.othervv_1032021
dc.identifier.otherav_b122b2f9-734f-4ecd-b692-cff2334e699d
dc.identifier.urihttp://hdl.handle.net/20.500.12627/3109
dc.identifier.urihttps://doi.org/10.1016/j.nmd.2020.09.001
dc.description.abstractIn patients with spinal muscular atrophy (SMA), obstructive sleep apnea syndrome (OSAS) constitutes an important cause of cardiovascular morbidity and mortality. We investigated heart rate variability (HRV) to evaluate the effects of non-invasive mechanical ventilation on cardiac autonomic dysfunction in patients with SMA and OSAS. Six patients with SMA (type 1 and 2) and six age- and sex-matched healthy children were consecutively enrolled. A whole-night diagnostic polysomnography was performed, and SMA patients with OSAS were given non-invasive mechanical ventilation therapy. HRV analysis was performed on the basis of whole-night electrocardiography recordings via a computer-base program. Apnea-hypopnea index (AHI) was 9.2 +/- 6.2/hr in SMA patients, while it was 0.4 +/- 0.5/hr in controls (p = 0.036). All SMA patients had OSAS, while none of the controls had OSAS (p = 0.012). Mean percentage of successive R wave of QRS complex (R-R) intervals > 50 ms was significantly lower in SMA patients than those in controls (p = 0.031). Significant correlations were found between AHI and high-frequency power, low/high-frequency ratio in wakefulness and in sleep (p 50 ms (p = 0.043). Our study demonstrates the beneficial effects of non-invasive mechanical ventilation on cardiac autonomic dysfunction in SMA patients with OSAS. (C) 2020 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSinirbilim ve Davranış
dc.subjectNEUROSCIENCES
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleThe effects of non-invasive mechanical ventilation on cardiac autonomic dysfunction in spinal muscular atrophy
dc.typeMakale
dc.relation.journalNEUROMUSCULAR DISORDERS
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , Cerrahpaşa Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü
dc.identifier.volume30
dc.identifier.issue10
dc.identifier.startpage845
dc.identifier.endpage850
dc.contributor.firstauthorID2287412


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record