dc.contributor.author | ÖZKAYA, GÜVEN | |
dc.contributor.author | UZUN, Hafize | |
dc.contributor.author | ŞİMŞEK, Gönül | |
dc.contributor.author | SÖZER, Volkan | |
dc.contributor.author | Gulcicek, Osman Bilgin | |
dc.contributor.author | Altinel, Yuksel | |
dc.contributor.author | Kose, Emin | |
dc.contributor.author | Karacaglar, Aysel | |
dc.contributor.author | Demirgan, Serdar | |
dc.date.accessioned | 2021-03-02T16:47:04Z | |
dc.date.available | 2021-03-02T16:47:04Z | |
dc.identifier.citation | Altinel Y., Kose E., Karacaglar A., Demirgan S., SÖZER V., ÖZKAYA G., Gulcicek O. B. , ŞİMŞEK G., UZUN H., "Systemic Amelioration via Curcumin in Rats following Splenectomy: Lipid Profile, Endothelial and Oxidative Damage", JOURNAL OF INVESTIGATIVE SURGERY, 2020 | |
dc.identifier.issn | 0894-1939 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_dff31bea-3f55-4c33-ae5e-c2a26a56e0d9 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/3280 | |
dc.identifier.uri | https://doi.org/10.1080/08941939.2020.1834651 | |
dc.description.abstract | Background We investigated the postsurgical effects of splenectomy with additional curcumin therapy, as an antioxidant, anti-inflammatory substance among the lipid profile and histopathological changes. Materials and Methods 32 rats were randomly divided into four groups: control group (L): laparotomy, sham group: splenectomy (S), splenectomy group treated with curcumin (SC) and splenectomy group treated with corn oil (SCO) for 28 days. The primary outcomes; total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), oxidized LDL (ox-LDL) very-low-density lipoprotein (VLDL) and lectin-type oxidized LDL receptor 1 (LOX-1), secondary outcomes: nuclear factor kappa B (NF-kB), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) were measured. Histopathological changes were examined in vascular, intestinal and lung tissues. The analysis was performed by ANOVA. Results TG, LDL, ox-LDL, and LOX-1 elevated in S group while reduced by curcumin compared with L group (p < 0.05). Serum and tissue levels of NF-kB and MDA were higher in S group and lower in SC group than L group (p < 0.05). Serum and intestinal levels of SOD and GPx increased in L group while reduced by curcumin (p < 0.05). Total histopathological scores of intestinal tissues were higher in S and SCO groups compared to L and SC groups (p < 0.05). No major changes in vascular and lung tissues were observed except the lymphoid follicles which was higher in S and SCO groups compared to L and SC groups (p < 0.05). Conclusions Curcumin partially improved the lipid profile dysfunction by modulating NF-kB, MDA, SOD, and GPx in splenectomized rats while less likely improving any vascular and alveolar regeneration. | |
dc.language.iso | eng | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | CERRAHİ | |
dc.title | Systemic Amelioration via Curcumin in Rats following Splenectomy: Lipid Profile, Endothelial and Oxidative Damage | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF INVESTIGATIVE SURGERY | |
dc.contributor.department | Istanbul Bagcilar Training & Research Hospital , , | |
dc.contributor.firstauthorID | 2287653 | |