dc.contributor.author | Tanyel, C. R. | |
dc.contributor.author | Gokcen-Rohlig, Bilge | |
dc.contributor.author | Bektas-Kayhan, K. | |
dc.contributor.author | Unur, M. | |
dc.contributor.author | Cakmakoglu, B. | |
dc.contributor.author | Cincin, Z. B. | |
dc.date.accessioned | 2021-03-03T12:01:15Z | |
dc.date.available | 2021-03-03T12:01:15Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Tanyel C. R. , Cincin Z. B. , Gokcen-Rohlig B., Bektas-Kayhan K., Unur M., Cakmakoglu B., "Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma", GENETICS AND MOLECULAR RESEARCH, cilt.12, sa.4, ss.5714-5720, 2013 | |
dc.identifier.issn | 1676-5680 | |
dc.identifier.other | av_2b682836-8e87-494c-b99d-f0ca1f8b7a80 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/33929 | |
dc.identifier.uri | https://doi.org/10.4238/2013.november.18.20 | |
dc.description.abstract | We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method from peripheral blood samples of both groups. There was a statistically significant difference between the control and patient groups for CCR5 59029 A/G genotypes (P 0.05). CCR5 59029 GG and CCR5-delta32 DD + ID genotype frequencies were significantly increased in Grade II-III OSCC patients compared with Grade I-II OSCC patients. In conclusion, these results suggested that the G allele of the CCR5 59029 polymorphism might be a risk factor due to the loss of receptor function that might cause increased inflammation leading to the development of OSCC. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıbbi Genetik | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | GENETİK VE HAYAT | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.title | Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma | |
dc.type | Makale | |
dc.relation.journal | GENETICS AND MOLECULAR RESEARCH | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 5714 | |
dc.identifier.endpage | 5720 | |
dc.contributor.firstauthorID | 8893 | |