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dc.contributor.authorÖZAYDIN, Ahmet
dc.contributor.authorONARAN, İlhan
dc.contributor.authorPOLAT, Erdal
dc.contributor.authorAKBAŞ, FAHRİ
dc.date.accessioned2021-03-02T17:08:03Z
dc.date.available2021-03-02T17:08:03Z
dc.date.issued2020
dc.identifier.citationAKBAŞ F., ÖZAYDIN A., POLAT E., ONARAN İ., "Lucilia sericata Larval Secretions Stimulating Wound Healing Effects on Rat Dermal Fibroblast Cells", RECORDS OF NATURAL PRODUCTS, cilt.14, ss.340-354, 2020
dc.identifier.issn1307-6167
dc.identifier.otherav_d7b2986b-d2e4-4467-8a34-a76de4aa563a
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/3630
dc.identifier.urihttps://doi.org/10.25135/rnp.180.20.03.1582
dc.description.abstractThe extract from larval Lucilia sericata is used clinically to promote wound healing and tissue regeneration. However, its effect and underlying mechanisms on fibroblast cells, which are involved in the wound healing process, are still poorly understood. This study aimed to examine the effects of larval secretions on dermal fibroblast activity and gene expression and to evaluate the wound healing potential of their major components. Primary rat fibroblasts were cultured and treated with larval secretions. Following the treatment, the cells were used to extract RNA for gene profiling. In addition, migration to the injury site was studied with the scratch healing assay. Our results showed that larval secretion accelerated the migration of the fibroblasts compared to the control cells and that several mRNAs were differentially expressed during a period of 72 h incubation. Additionally, we analyzed the chemical composition of larval secretions and showed that fumaric acid, ferulic acid, and p-coumaric acid, which were selected and identified for their major components, enhanced the migration of the fibroblasts. Therefore, these results indicate that L. sericata larval secretions could modulate the mRNA expression of some wound healing-related genes of the fibroblasts and contain the effective components for wound healing.
dc.language.isoeng
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectDiğer
dc.subjectTemel Bilimler
dc.subjectKİMYA, TIP
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, UYGULAMALI
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectBİTKİ BİLİMLERİ
dc.titleLucilia sericata Larval Secretions Stimulating Wound Healing Effects on Rat Dermal Fibroblast Cells
dc.typeMakale
dc.relation.journalRECORDS OF NATURAL PRODUCTS
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , Tıp Fakültesi , Temel Tıp Bilimleri Bölümü
dc.identifier.volume14
dc.identifier.issue5
dc.identifier.startpage340
dc.identifier.endpage354
dc.contributor.firstauthorID2286165


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