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Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients

dc.contributor.authorSen, F.
dc.contributor.authorUgurel, E.
dc.contributor.authorOzbek, U.
dc.contributor.authorDemirkan, A.
dc.contributor.authorUstuner, Z.
dc.contributor.authorDerin, D.
dc.contributor.authorVural, B.
dc.contributor.authorSaip, P.
dc.contributor.authorCamlica, H.
dc.contributor.authorEralp, Y.
dc.date.accessioned2021-03-03T12:42:16Z
dc.date.available2021-03-03T12:42:16Z
dc.date.issued2011
dc.identifier.citationSaip P., Sen F., Vural B., Ugurel E., Demirkan A., Derin D., Eralp Y., Camlica H., Ustuner Z., Ozbek U., "Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients", JOURNAL OF BUON, cilt.16, sa.2, ss.241-246, 2011
dc.identifier.issn1107-0625
dc.identifier.otherav_2f8fae4f-7b7b-476a-b9ee-5f60cfa43a58
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/36504
dc.description.abstractPurpose: Many of commonly used chemotherapeutics in lung cancer treatment are metabolized by glutathione-S transferases (GSTs). The placental isoform of GST (GSTP1) is the most abundant isoform in the lung. Polymorphisms within the GSTP1 may result in alterations in enzyme activity and change sensitivity to platinum-based chemotherapy. We investigated whether the polymorphism within the exons 5 and 6 of GSTP1 gene may change response to therapy, time to tumor progression (TTP) and overall survival in small cell lung cancer (SCLC) patients.
dc.language.isoeng
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.titleGlutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients
dc.typeMakale
dc.relation.journalJOURNAL OF BUON
dc.contributor.departmentEskişehir Osmangazi Üniversitesi , ,
dc.identifier.volume16
dc.identifier.issue2
dc.identifier.startpage241
dc.identifier.endpage246
dc.contributor.firstauthorID30039


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