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Ancient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis

dc.contributor.authorIvanov, Maya I.
dc.contributor.authorPark, Yong Hwan
dc.contributor.authorRemmers, Elaine F.
dc.contributor.authorLee, Wonyong
dc.contributor.authorOmbrello, Amanda K.
dc.contributor.authorChung, Lawton K.
dc.contributor.authorZhao Shilei, Zhao Shilei
dc.contributor.authorStone, Deborah L.
dc.contributor.authorLoeven, Nicole A.
dc.contributor.authorBarron, Karyl S.
dc.contributor.authorHoffmann, Patrycja
dc.contributor.authorNehrebecky, Michele
dc.contributor.authorAkkaya-Ulum, Yeliz Z.
dc.contributor.authorSAĞ, ERDAL
dc.contributor.authorBalci-Peynircioglu, Banu
dc.contributor.authorAksentijevich, Ivona
dc.contributor.authorGül, Ahmet
dc.contributor.authorRotimi, Charles N.
dc.contributor.authorChen, Hua
dc.contributor.authorBliska, James B.
dc.contributor.authorÖZEN, SEZA
dc.contributor.authorKastner, Daniel L.
dc.contributor.authorShriner, Daniel
dc.contributor.authorChae, Jae Jin
dc.date.accessioned2021-03-02T17:27:24Z
dc.date.available2021-03-02T17:27:24Z
dc.date.issued2020
dc.identifier.citationPark Y. H. , Remmers E. F. , Lee W., Ombrello A. K. , Chung L. K. , Zhao Shilei Z. S. , Stone D. L. , Ivanov M. I. , Loeven N. A. , Barron K. S. , et al., "Ancient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis", NATURE IMMUNOLOGY, cilt.21, ss.857-876, 2020
dc.identifier.issn1529-2908
dc.identifier.otherav_c923c4e2-4d0a-4152-8906-ee34fb17acec
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/3800
dc.identifier.urihttps://doi.org/10.1038/s41590-020-0705-6
dc.description.abstractFamilial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues show that mutant pyrin better resists suppression by the plague bacteriumYersinia pestisand may have been positively selected in human Middle Eastern populations.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTemel Bilimler
dc.titleAncient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis
dc.typeMakale
dc.relation.journalNATURE IMMUNOLOGY
dc.contributor.departmentNational Institutes of Health (NIH) - USA , ,
dc.identifier.volume21
dc.identifier.issue8
dc.identifier.startpage857
dc.identifier.endpage876
dc.contributor.firstauthorID2283171


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