dc.contributor.author | Ergin Kızılçay, Gamze | |
dc.contributor.author | Toker, Sıdıka | |
dc.date.accessioned | 2021-03-02T17:28:22Z | |
dc.date.available | 2021-03-02T17:28:22Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Ergin Kızılçay G., Toker S., "Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone", İstanbul journal of pharmacy, cilt.50, sa.2, ss.95-102, 2020 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_1823f500-ef0b-4be3-a365-9455998384d7 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/3833 | |
dc.identifier.uri | https://doi.org/10.26650/istanbuljpharm.2020.0003 | |
dc.identifier.uri | https://dergipark.org.tr/tr/download/article-file/1259669 | |
dc.description.abstract | Background and Aims: In this study, simple, accurate and precise spectrophotometric methods were developed for the determination of five 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors in pure and pharmaceutical dosage forms. Methods: In the developed methods, atorvastatin fluvastatin, pitavastatin, rosuvastatin and simvastatin were used in this class of drugs called statins. The methods were based on the charge-transfer reaction of n-electron donor drugs with π-acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). All variables such as temperature, time, reaction medium, amount of reagent were examined for optimal formation of complexes to be given by the drugs with DDQ and optimal conditions were determined. Results: The linearity ranges for atorvastatin, fluvastatin, pitavastatin, rosuvastatin and simvastatin were found to be 0.5-50, 1-6, 2.5-50, 5-25 and 5-50 μg/mL, respectively. Conclusion: The proposed methods were successfully applied to both the pure and the pharmaceutical dosage forms | |
dc.language.iso | tur | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Analitik Kimya | |
dc.title | Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone | |
dc.type | Makale | |
dc.relation.journal | İstanbul journal of pharmacy | |
dc.contributor.department | İstanbul Üniversitesi , Eczacılık Fakültesi , Temel Eczacılık Bilimleri Bölümü | |
dc.identifier.volume | 50 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 95 | |
dc.identifier.endpage | 102 | |
dc.contributor.firstauthorID | 2214147 | |