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dc.contributor.authorOzluk, Yasemin
dc.contributor.authorKeskin, Metin
dc.contributor.authorGulluoglu, Mine
dc.contributor.authorOnder, Semen
dc.contributor.authorYegen, Gulcin
dc.contributor.authorBalik, Emre
dc.contributor.authorGundogdu, Goekcen
dc.contributor.authorDogan, Serap
dc.date.accessioned2021-03-03T13:17:07Z
dc.date.available2021-03-03T13:17:07Z
dc.date.issued2015
dc.identifier.citationGulluoglu M., Yegen G., Ozluk Y., Keskin M., Dogan S., Gundogdu G., Onder S., Balik E., "Tumor Budding Is Independently Predictive for Lymph Node Involvement in Early Gastric Cancer", INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, cilt.23, sa.5, ss.349-358, 2015
dc.identifier.issn1066-8969
dc.identifier.otherav_331b999e-8dab-495e-bb7a-8879e84497d0
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/38634
dc.identifier.urihttps://doi.org/10.1177/1066896915581200
dc.description.abstractBackground. The most important prognostic factor for early gastric cancer (EGC) is the lymph node status. It is important to predict early lesions without lymph node metastasis (LNM) before proceeding to radical surgery in locally excised lesions. Tumor budding is a feature known to be related to aggressive tumor behavior in several solid tumors. We aimed to assess the predictive value of tumor budding for LNM in pT1a and pT1b gastric cancer. Methods. We retrospectively investigated radical gastrectomy specimens for of 126 EGC patients and assess the possible relation between the clinicopathologic features, including age, gender, tumor location, tumor size, macroscopic tumor type, histologic differentiation, depth and width of submucosal invasion, lymphovascular invasion, and tumor budding with lymph node involvement. Results. Among the 126 EGCs, 38 were stages as pT1a and 88 as pT1b. LNM rate in pT1a tumors was 13% whereas it was 33% in pT1b tumors. Tumor budding was the only factor significantly and independently related to LNM in pT1a patients. Female gender and tumor budding were found to be independent risk factors in pT1b group. Other clinicopathologic features were not related to LNM. Conclusion. Based on these results, we suggest that budding is a promising parameter to assess for prediction of LNM in EGC removed by endoscopic surgery, and to decide on the appropriate surgical approach.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectTemel Bilimler
dc.subjectPATOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectCERRAHİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.titleTumor Budding Is Independently Predictive for Lymph Node Involvement in Early Gastric Cancer
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume23
dc.identifier.issue5
dc.identifier.startpage349
dc.identifier.endpage358
dc.contributor.firstauthorID60175


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