dc.contributor.author | Polat, Emre Can | |
dc.contributor.author | Ozbek, EMİN | |
dc.contributor.author | Emrence, Zeliha | |
dc.contributor.author | Ustek, Duran | |
dc.contributor.author | Otunctemur, Alper | |
dc.contributor.author | Ozcan, Levent | |
dc.date.accessioned | 2021-03-03T13:21:54Z | |
dc.date.available | 2021-03-03T13:21:54Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Ozbek E., Polat E. C. , Ozcan L., Otunctemur A., Emrence Z., Ustek D., "TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology", JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, cilt.39, sa.1, ss.237-242, 2013 | |
dc.identifier.issn | 1341-8076 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_33943344-b15e-4892-ba22-229fd4543172 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/38932 | |
dc.identifier.uri | https://doi.org/10.1111/j.1447-0756.2012.01942.x | |
dc.description.abstract | Aim: In experimental studies, lysyl oxidase like-1 (LOX-L1) (-/-) mice were shown to have similar pelvic floor dysfunction to female rats. LOX-L1 levels in endopelvic fascia decrease as a result of increasing births in women with pelvic prolapse. For these reasons, we investigated the LOX-L1 gene polymorphism, which has an important role in connective tissue and collagenous metabolism in stress urinary incontinence (SUI). Materials and Methods: A total of 87 women with SUI who underwent normal vaginal delivery and 87 controls were involved in the study. Single nucleotide gene polymorphisms in LOX-L1's rs1048661, G > T, pArg141Leu, Exon-1 SmaI; rs3825942, C > T, pGly153Asp, Hinf-1 and rs2165241, C > T, Intron-1 BsrI regions were searched. The results were statistically compared as alleles with 3 x 2 ?2-test. Results: A total of 32 (34%) GG, 20 (21%) GT, 42 (45%) TT, 32 (37%) GG, 43 (39%) GT, 21 (24%) TT polymorphisms in rs1048661; 30 (36%) CC, 16 (19%) CT, 37 (45%) TT, 41 (59%) CC, 15 (22%) CT, 13 (19%) TT polymorphisms in rs2165241; and 63 (72%) CC, 21 (24%) CT, 3 (4%) TT; 48 (6%) CC, 22 (30%) CT, 3 (4%) TT polymorphisms in rs3825942 were found in patients and the control group, respectively. In patients, the TT polymorphism in the rs1048661 and rs2165241 region were found to be significant. Conclusions: The homozygote TT polymorphism in the rs1048661 and rs2165241 region of LOX-L1 gene may be responsible from SUI physiopathology. | |
dc.language.iso | eng | |
dc.subject | Kadın Hastalıkları ve Doğum | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | KADIN HASTALIKLARI & DOĞUM | |
dc.title | TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | |
dc.contributor.department | Balikligol Govt Hosp , , | |
dc.identifier.volume | 39 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 237 | |
dc.identifier.endpage | 242 | |
dc.contributor.firstauthorID | 90205 | |