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Isatin analogs as novel inhibitors of Candida spp. beta-carbonic anhydrase enzymes

dc.contributor.authorSupuran, Claudiu T.
dc.contributor.authorGuzel-Akdemir, Ozlen
dc.contributor.authorKarali, Nilgün Lütfiye
dc.contributor.authorAKDEMİR, ATİLLA
dc.date.accessioned2021-03-03T13:23:25Z
dc.date.available2021-03-03T13:23:25Z
dc.date.issued2016
dc.identifier.citationAKDEMİR A., Guzel-Akdemir O., Karali N. L. , Supuran C. T. , "Isatin analogs as novel inhibitors of Candida spp. beta-carbonic anhydrase enzymes", BIOORGANIC & MEDICINAL CHEMISTRY, cilt.24, sa.8, ss.1648-1652, 2016
dc.identifier.issn0968-0896
dc.identifier.otherav_33ca3b1b-78dd-4664-a2a1-0072f8a4662a
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/39046
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2016.02.036
dc.description.abstractEnzyme inhibition data of structurally novel isatin-containing sulfonamides were determined for two carbonic anhydrases (CAs, EC 4.2.1.1) from pathogenic Candida species (CaNce103 from C. albicans and CgNce103 from C. glabrata). The compounds show K-I values in the low nanomolar range for the fungal CAs, while they have significantly higher K-I values for the human CAs. Homology models were constructed for the CaNce103 and CgNce103 and subsequently the ligands were docked into these models to rationalize their enzyme inhibitory properties. (C) 2016 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectKİMYA, ORGANİK
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleIsatin analogs as novel inhibitors of Candida spp. beta-carbonic anhydrase enzymes
dc.typeMakale
dc.relation.journalBIOORGANIC & MEDICINAL CHEMISTRY
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , Eczacılık Fakültesi , Farmakoloji Anabilim Dalı
dc.identifier.volume24
dc.identifier.issue8
dc.identifier.startpage1648
dc.identifier.endpage1652
dc.contributor.firstauthorID231599


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