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dc.contributor.authorYanar, Karolin
dc.contributor.authorBelce, Ahmet
dc.contributor.authorCelikten, Mert
dc.contributor.authorAydin, Seval
dc.contributor.authorKansu, Ahmet Dogukan
dc.contributor.authorMengi, Murat
dc.contributor.authorErdogan, Mehmet Evren
dc.contributor.authorCebe, Tamer
dc.contributor.authorCakatay, Ufuk
dc.date.accessioned2021-03-03T13:29:11Z
dc.date.available2021-03-03T13:29:11Z
dc.date.issued2017
dc.identifier.citationErdogan M. E. , Aydin S., Yanar K., Mengi M., Kansu A. D. , Cebe T., Belce A., Celikten M., Cakatay U., "The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer's disease model", METABOLIC BRAIN DISEASE, cilt.32, sa.4, ss.1017-1031, 2017
dc.identifier.issn0885-7490
dc.identifier.otherav_345140e0-5dcc-4d05-a889-7b411b66de3c
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/39382
dc.identifier.urihttps://doi.org/10.1007/s11011-017-9983-6
dc.description.abstractWhile the deterioration of insulin-glucose metabolism (IGM), impaired redox homeostasis (IRH), beta-amyloid accumulation was reported in Sporadic Alzheimer's Disease (SAD) model, aforementioned factors related to lipoic acid administration and anthropometric indexes (AIs) are not yet studied with integrative approach. beta-amyloid accumulation, redox homeostasis biomarkers and AIs are investigated in SAD model. Streptozotocin-induced inhibition of insulin-signaling cascade but not GLUT-2 and GLUT-3 transporters takes a role in beta-amyloid accumulation. Inhibition types are related to IRH in cortex, hippocampus and systemic circulation. Lipoic acid (LA) shows both antioxidant and prooxidant effect according to the anatomical location. LA administration also leads to improved AIs during GLUT-2 inhibition and cortical redox status in GLUT-3 inhibited group. Optimal LA action could be possible if its redox behavior is balanced to antioxidant effect. Diagnostic usage of systemic IRH parameters as biomarkers and their possible correlations with deteriorated IGM should be investigated.
dc.language.isoeng
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleThe effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer's disease model
dc.typeMakale
dc.relation.journalMETABOLIC BRAIN DISEASE
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , ,
dc.identifier.volume32
dc.identifier.issue4
dc.identifier.startpage1017
dc.identifier.endpage1031
dc.contributor.firstauthorID90392


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