dc.contributor.author | BAYOĞLU, Burcu | |
dc.contributor.author | Arslan, Caner | |
dc.contributor.author | CENGİZ, Müjgan | |
dc.contributor.author | DİRİCAN, Ahmet | |
dc.contributor.author | Junusbekov, Yerik | |
dc.date.accessioned | 2021-03-02T17:32:49Z | |
dc.date.available | 2021-03-02T17:32:49Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Junusbekov Y., BAYOĞLU B., CENGİZ M., DİRİCAN A., Arslan C., "AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease", IRISH JOURNAL OF MEDICAL SCIENCE, cilt.189, sa.3, ss.885-894, 2020 | |
dc.identifier.issn | 0021-1265 | |
dc.identifier.other | av_840b30e3-b286-4a01-aa2e-be4247edda59 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/4008 | |
dc.identifier.uri | https://doi.org/10.1007/s11845-019-02166-6 | |
dc.description.abstract | Background Peripheral arterial diseases (PAD) refer to the arterial diseases other than coronary arteries and the aorta. Atherosclerosis is the major cause of PAD. Renin angiotensin aldosterone system (RAAS)-related genes were associated with cardiovascular diseases. Angiotensin II is the pro-inflammatory, proliferative and vasoconstrictor effector of RAAS in the vascular system. Aims In this study, we aimed to investigate whether the effects of the angiotensinogen (AGT) rs699 (M268T), angiotensin-converting enzyme (ACE) I/D (rs1799752), angiotensin II receptor type 1 (AGTR1) (A1166C) rs5186, and angiotensin II receptor type 2 (AGTR2) rs35474657 variants were associated with PAD etiology due to atherosclerotic involvement of aorta-iliac and femoro-popliteal artery occlusions. Methods AGTrs699,AGTR1rs5186,ACEI/D (rs1799752),AGTR2rs35474657 gene variants were determined by real-time polymerase chain reaction (RT-PCR) in 63 PAD patients (33 femoro-popliteal, 30 aorta-iliac) and 70 healthy controls. Results Although there was no significant relationship in the genotype frequencies ofAGTrs699,AGTR1rs5186,ACEI/D (rs1799752), andAGTR2rs35474657 variants between PAD and control groups (p > 0.05),AGTrs699 TT genotype was significantly associated with fasting glucose (p = 0.023) in PAD patients. Besides, CC genotype of rs699 was significantly related with HDL-cholesterol levels (p = 0.020) in PAD group. Furthermore,AGTR1rs5186 CC genotype carriers demonstrated significantly higher LDL-cholesterol (p = 0.034) and triglycerides levels (p = 0.007). Conclusions This report is the first to show an association between RAAS-related gene variants and their relation with the biochemical characteristics of PAD and suggests that RAAS-associated gene variants may have significant roles in cardiovascular related phenotypes of PAD patients. | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | TIP, GENEL & İÇECEK | |
dc.subject | Klinik Tıp | |
dc.subject | Tıp | |
dc.subject | Temel Tıp Bilimleri | |
dc.title | AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease | |
dc.type | Makale | |
dc.relation.journal | IRISH JOURNAL OF MEDICAL SCIENCE | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 189 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 885 | |
dc.identifier.endpage | 894 | |
dc.contributor.firstauthorID | 2285099 | |