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dc.contributor.authorAKSEKILI, Ertugrul
dc.contributor.authorUyar, Yavuz
dc.contributor.authorUNALDI, Ozlem
dc.contributor.authorOzkul, Aykut
dc.contributor.authorKorukluoglu, Gulay
dc.contributor.authorErtek, Mustafa
dc.contributor.authorKalaycioglu, Atila T.
dc.contributor.authorDURMAZ, Riza
dc.date.accessioned2021-03-03T13:48:16Z
dc.date.available2021-03-03T13:48:16Z
dc.date.issued2012
dc.identifier.citationKalaycioglu A. T. , DURMAZ R., Uyar Y., UNALDI O., AKSEKILI E., Ozkul A., Korukluoglu G., Ertek M., "Lack of genetic diversity in Crimean-Congo hemorrhagic fever viruses in Turkey: Assessment of present and future patterns of disease", JOURNAL OF MEDICAL VIROLOGY, cilt.84, sa.3, ss.471-478, 2012
dc.identifier.issn0146-6615
dc.identifier.otherav_361af27c-8f72-4fc3-95d3-4010a352b157
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/40540
dc.identifier.urihttps://doi.org/10.1002/jmv.22224
dc.description.abstractCrimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis which is common in Africa, Asia, Eastern Europe, and the Balkan Peninsula. CCHF has been reported in Turkey with high frequency since 2002. The aim of the present study was to investigate the genetic diversity and genetic relationship between CCHF virus (CCHFV) isolates derived from infected patients over a 2-year period (2009 and 2010) in several provinces of Turkey. Serum samples (n=48) were selected from CCHFV RNA positive patients and subjected to sequence analysis of the gene regions encoding the S (48 samples) and M (14 samples) segments. The nucleotide sequence alignments showed that the nucleic acid relatedness of CCHFV isolates ranged from 95.7% to 100% and from 93.7% to 100% for S and M segments, respectively. Phylogenetic analysis of both segment sequences revealed that CCHFV isolates circulating in Turkey belonged to the European lineage I and were closely related to the viruses found in the Eastern European-Russian and Balkan Peninsula. The M gene segment-based phylogenetic analysis suggested that 2/14 CCHFV isolates (KYSR3159/09 and YZGT714/10) had additional genetic variations. The results of the present study confirmed that the CCHFV isolates present in Turkey associated with human disease had high genetic homology in S segment, but some variability in the M segment of the RNA. J. Med. Virol. 84:471478, 2012. (C) 2012 Wiley Periodicals, Inc.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectViroloji
dc.subjectMikrobiyoloji ve Klinik Mikrobiyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.subjectVİROLOJİ
dc.titleLack of genetic diversity in Crimean-Congo hemorrhagic fever viruses in Turkey: Assessment of present and future patterns of disease
dc.typeMakale
dc.relation.journalJOURNAL OF MEDICAL VIROLOGY
dc.contributor.departmentRefik Saydam Hifzissihha Merkezi Baskanligi , ,
dc.identifier.volume84
dc.identifier.issue3
dc.identifier.startpage471
dc.identifier.endpage478
dc.contributor.firstauthorID87970


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