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dc.contributor.authorTuzuner, Mete Bora
dc.contributor.authorSeyhan, Fatih
dc.contributor.authorVelidedeoglu, Mehmet
dc.contributor.authorCalay, Zerrin
dc.contributor.authorIlvan, Sennur
dc.contributor.authorIsbir, Turgar
dc.contributor.authorYilmaz-Aydogan, Hülya
dc.contributor.authorOzturk, Oguz
dc.contributor.authorKucukhuseyin, Ozlem
dc.contributor.authorDaglar-Aday, Aynur
dc.contributor.authorOzturk, Tulin
dc.contributor.authorEronat, Allison Pinar
dc.contributor.authorSaygili, Neslihan
dc.contributor.authorKisakesen, Halil Ibrahim
dc.date.accessioned2021-03-03T13:54:12Z
dc.date.available2021-03-03T13:54:12Z
dc.date.issued2015
dc.identifier.citationOzturk T., Kucukhuseyin O., Eronat A. P. , Tuzuner M. B. , Daglar-Aday A., Saygili N., Kisakesen H. I. , Seyhan F., Velidedeoglu M., Calay Z., et al., "Preliminary Study: Prominent miRNAs of Breast Malignant Tissues Compared to Normal Tissues in Turkish Patients with Breast Cancer", ANTICANCER RESEARCH, cilt.35, sa.10, ss.5425-5432, 2015
dc.identifier.issn0250-7005
dc.identifier.otherav_36b58cac-599c-4e6b-81c9-a07846b6b40e
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/40918
dc.description.abstractmiRNA involvement has been observed in almost every type of cancer, including breast cancer. The etiology of abnormal expression of miRNAs in cancer is still not clearly understood. In order to obtain insight into miRNA deregulation in breast cancer, we analyzed expression levels of five breast cancer-related miRNAs, miRNA21, miRNA155, miRNA19a, miRNA17-5p and let7a miRNA, in both malignant and neighboring non-tumoral paraffin-embedded tissues of 47 patients with invasive ductal breast cancer. The targeted miRNAs, and a reference snRNA, U6, were analyzed by real-time polymerase chain reaction. let7a Levels were significantly lower in patients with lymphatic invasion than in those without (p=0.047). miR21 was down-regulated in 93.3% of patients with necrosis [p=0.017 (Fisher's exact test (FE))], while at least one oncogenic miRNA was up-regulated in 87.3% of the patients with invasive ductal carcinoma [p=0.009 (FE)]. In addition, tumor-suppressor miRNA was down-regulated or unaltered in 65.8% of the patients with tumor grade 2 or 3 and in all with grade 1 [p=0.047 (FE)]. Based on this preliminary study, we suggest that these miRNAs, especially let7a and miRNA21, might be useful markers in follow-up of breast cancer and in prognosis.
dc.language.isoeng
dc.subjectOncology
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectHealth Sciences
dc.titlePreliminary Study: Prominent miRNAs of Breast Malignant Tissues Compared to Normal Tissues in Turkish Patients with Breast Cancer
dc.typeMakale
dc.relation.journalANTICANCER RESEARCH
dc.contributor.departmentİstanbul Teknik Üniversitesi , ,
dc.identifier.volume35
dc.identifier.issue10
dc.identifier.startpage5425
dc.identifier.endpage5432
dc.contributor.firstauthorID55085


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