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dc.contributor.authorTÜRKYILMAZ, İsmet Burcu
dc.contributor.authorYANARDAĞ, Refiye
dc.contributor.authorBilgin Sokmen, Bahar
dc.date.accessioned2021-03-02T17:36:51Z
dc.date.available2021-03-02T17:36:51Z
dc.identifier.citationTÜRKYILMAZ İ. B. , Bilgin Sokmen B., YANARDAĞ R., "Alpha-lipoic acid prevents brain injury in rats administered with valproic acid", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2020
dc.identifier.issn1095-6670
dc.identifier.othervv_1032021
dc.identifier.otherav_39e34644-14f8-4c55-9881-4e6666e174b7
dc.identifier.urihttp://hdl.handle.net/20.500.12627/4142
dc.identifier.urihttps://doi.org/10.1002/jbt.22580
dc.description.abstractValproic acid (VPA) is an effective drug, which is preferred for the treatments of epilepsy and various kinds of seizures. Nonetheless, VPA has many life-threatening side effects associated with free radical production. Alpha-lipoic acid (ALA) is a powerful antioxidant, which can scavenge reactive oxygen species (ROS). The effects of ALA against VPA-stimulated brain injury were investigated. In this study, Sprague-Dawley rats were divided as four groups: Group I, control rats; Group II, ALA-administered rats (50 mg/kg/d); Group III, VPA-administered rats (0.5 g/kg/d); Group IV: VPA- and ALA-administered rats at the same dose and time. According to the results, VPA increased lipid peroxidation, protein carbonyl, advanced oxidation protein products, total oxidant status, nitric oxide levels and glutathione-S-transferase, adenosine deaminase, xanthine oxidase activities, decreased glutathione, total antioxidant capacity levels, catalase, superoxide dismutase, glutathione peroxidase, sodium-potassium ATPase, and paraoxonase activities. Treatment with ALA reversed these effects. In conclusion, we may suggest that ALA may be a good candidate for prevention of VPA-induced brain injury.
dc.language.isoeng
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTOKSİKOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleAlpha-lipoic acid prevents brain injury in rats administered with valproic acid
dc.typeMakale
dc.relation.journalJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , Mühendislik Fakültesi , Kimya Bölümü
dc.contributor.firstauthorID2284043


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