The Ser128Arg polymorphism of E-selectin gene is not associated with polycystic ovary syndrome

Abstract

Objective: Low-grade chronic inflammation and endothelial dysfunction have important role in the pathogenesis of polycystic ovary syndrome (PCOS). E-selectin is a cell adhesion molecule involved in first attachment and transmigration of leukocytes to activated endothelium in conditions with chronic inflammation. This study examined for the first time the possible association of Ser128Arg (c.561 A>C) single nucleotide polymorphism (SNP) of E-selectin gene with the occurrence of PCOS, and evaluates the relationship between genotypes and clinical/biochemical characteristics of PCOS.