dc.contributor.author | BERNARD, GC | |
dc.contributor.author | BOURRE, JME | |
dc.contributor.author | LEFAUCONNIER, JMA | |
dc.contributor.author | DURAND, GA | |
dc.contributor.author | ZIYLAN, ZY | |
dc.date.accessioned | 2021-03-03T14:23:28Z | |
dc.date.available | 2021-03-03T14:23:28Z | |
dc.date.issued | 1992 | |
dc.identifier.citation | ZIYLAN Z., BERNARD G., LEFAUCONNIER J., DURAND G., BOURRE J., "EFFECT OF DIETARY N-3 FATTY-ACID DEFICIENCY ON BLOOD-TO-BRAIN TRANSFER OF SUCROSE, ALPHA-AMINOISOBUTYRIC-ACID AND PHENYLALANINE IN THE RAT", NEUROSCIENCE LETTERS, cilt.137, sa.1, ss.9-13, 1992 | |
dc.identifier.issn | 0304-3940 | |
dc.identifier.other | av_393cb389-821a-4e9f-98f7-4610726843ef | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/42495 | |
dc.identifier.uri | https://doi.org/10.1016/0304-3940(92)90286-g | |
dc.description.abstract | Possible alterations in blood-to-brain unidirectional transport of sucrose (mol. wt., 342), alpha-aminoisobutyric acid (mol. wt., 104), and L-phenylalanine (mol. wt., 165) induced by a diet deficient in n-3 polyunsaturated fatty acids were studied with respect to blood-brain barrier function. Two groups of rats were for to two generations with a semisynthetic diet. One group of rats was fed a peanut oil + rapeseed oil diet which contained both essential fatty acids: linoleic acid (18:2 n-6) and alpha-linolenic acid, (18:3 n-3). Another group was fed a diet of peanut oil, this diet (containing 18:2 n-6) was deficient in alpha-linolenic acid. The experiments were performed at 6 months of age. Unidirectional transfer rate constants (K(i)) of sucrose, alpha-aminoisobutyric acid and L-phenylalanine were measured. The diet based on peanut oil (deficient in n-3) caused a greater blood-to-brain transport of sucrose but not of alpha-aminoisobutyric acid or L-phenylalanine. These observations indicate that regardless of the mechanisms involved, alterations in essential fatty acids induced by diet can modulate to some extent the blood-brain transport of hydrophilic molecules without a carrier. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Temel Bilimler | |
dc.subject | NEUROSCIENCES | |
dc.subject | Sinirbilim ve Davranış | |
dc.subject | Yaşam Bilimleri | |
dc.title | EFFECT OF DIETARY N-3 FATTY-ACID DEFICIENCY ON BLOOD-TO-BRAIN TRANSFER OF SUCROSE, ALPHA-AMINOISOBUTYRIC-ACID AND PHENYLALANINE IN THE RAT | |
dc.type | Makale | |
dc.relation.journal | NEUROSCIENCE LETTERS | |
dc.contributor.department | , , | |
dc.identifier.volume | 137 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 9 | |
dc.identifier.endpage | 13 | |
dc.contributor.firstauthorID | 113349 | |