Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats
Tarih
2015Yazar
Midi, Ahmet
Purisa, SEVİM
AK, Dursun
Lacin, Berna
BULUT, Guven
ORAK, Mehmet Mufit
Üst veri
Tüm öğe kaydını gösterÖzet
Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.
Koleksiyonlar
- Makale [92796]