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dc.contributor.authorErturk, Nurten
dc.contributor.authorCurgunlu, Aslı
dc.contributor.authorVehid, Suphi
dc.contributor.authorKarter, Yesari
dc.contributor.authorMihmanli, I
dc.contributor.authorAyan, F
dc.date.accessioned2021-03-03T14:36:14Z
dc.date.available2021-03-03T14:36:14Z
dc.date.issued2003
dc.identifier.citationKarter Y., Curgunlu A., Erturk N., Vehid S., Mihmanli I., Ayan F., "Effects of low and high doses of atorvastatin on arterial compliance", JAPANESE HEART JOURNAL, cilt.44, sa.6, ss.953-961, 2003
dc.identifier.issn0021-4868
dc.identifier.otherav_3a7a0725-b6f1-4019-b9f2-596944976d79
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/43274
dc.identifier.urihttps://doi.org/10.1536/jhj.44.953
dc.description.abstractAt the beginning of atherosclerosis before evidence of morphological lesions or plaques, vascular distensibility or arterial compliance decreased gradually. This endothelial dysfunction is regarded as art early feature of atherosclerosis. In a randomized, double-blind study design, group I (12 patients; 7 males, 5 females) with serum LDL-C levels higher than 170 mg/dL and without any other risk factor for atherosclerosis received three months of 20 mg/day atorvastatin treatment while group II (8 males, 4 females) with the same characteristics received 80 mg/day. Baseline and posttreatment serum lipid fractions and arterial compliance were measured. Arterial compliance was measured noninvasively in the left common carotid artery with color Doppler ultrasound. Atorvastatin reduced total cholesterol (TC), LDL-C, and triglyceride levels by 32% (P < 0.001). 40.8% (P < 0.001), and 19% (P < 0.001), respectively, and increased HDL-C by 6.9% (P = 0.002) in the first group. In the second group these reductions were 33.5% (P < 0.001), 46.2% (P < 0.001), and 26.78% (P < 0.001), respectively, and the increase in HDL was 7.8% (P = 0.03). It was observed that the decrease in serum TC. LDL-C and triglyceride levels were significantly higher in the second group than the first group. With atorvastatin, the distensibility coefficient (DC) and compliance coefficient (CC) increased front 18.7 +/- 3.14 to 21.3 +/- 2.9 10(-3).kPa(-1) (P < 0.001) and from 0.69 +/- 0.05 to 0.77 +/- 0.03 mm(2).kPa(-1) (P < 0.001) in the first group while they changed from 18.3 +/- 3.6 to 21.9 +/- 3.0 10(-3).kPa(-1) (P < 0.001) and from 0.70 +/- 0.04 to 0.81 +/- 0.01 mm(2).kPa(-1) (P < 0.001) respectively, in the second group. DC and CC increased in both groups, but the differences between the groups were not significant. High doses of atorvastatin reduce blood lipid levels more than conventional doses, however, the change in compliance is not dose-dependent. As endothelial dysfunction is regarded as an early feature of atherosclerosis, there would be no need to administer aggressive doses in a patient without any risk factors other than hyperlipidemia.
dc.language.isoeng
dc.subjectKardiyoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCARDIAC ve CARDIOVASCULAR SİSTEMLER
dc.titleEffects of low and high doses of atorvastatin on arterial compliance
dc.typeMakale
dc.relation.journalJAPANESE HEART JOURNAL
dc.contributor.department, ,
dc.identifier.volume44
dc.identifier.issue6
dc.identifier.startpage953
dc.identifier.endpage961
dc.contributor.firstauthorID61731


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