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dc.contributor.authorBAYINDIR, C
dc.contributor.authorGazioglu, N
dc.contributor.authorBALAK, N
dc.date.accessioned2021-03-03T14:44:30Z
dc.date.available2021-03-03T14:44:30Z
dc.date.issued1997
dc.identifier.citationBAYINDIR C., BALAK N., Gazioglu N., "Prolactin-secreting carcinoma of the pituitary: clinicopathological and immunohistochemical study of a case with intracranial and intraspinal dissemination", BRITISH JOURNAL OF NEUROSURGERY, cilt.11, sa.4, ss.350-355, 1997
dc.identifier.issn0268-8697
dc.identifier.otherav_3b300771-fc8c-4fb3-b492-237059fa8d46
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/43751
dc.identifier.urihttps://doi.org/10.1080/02688699746177
dc.description.abstractA 32-year-old female patient with a primary adenohypophyseal neoplasm that rapidly progressed to a fatal outcome is presented. The time interval between her admission to the hospital and her death was 3 months. Despite dopamine agonist therapy, local invasion as well as frontal and spinal cord metastases at Th 10-12 region developed, and four surgical resections were performed. The serum prolactin levels were high. Both the primary pituitary tumour and all the metastatic tumours had the same histological findings and immunohistochemical reactions. Each was composed of pleomorphic chromophobic cells with enlarged nuclei. Mitoses and necroses were frequent. Immunostains revealed prolactin in the tumour cells. A literature review revealed that in most of the pituitary carcinomas as in our case hyperprolactinaemia did not respond to medical therapy and the histopathological appearance of the tumour has not correlated with the aggressive behaviour of the tumour. It may therefore be considered that at least some of the cases with metastases in prolactin secreting pituitary carcinomas could be the result of hyperprolactinaemia itself.
dc.language.isoeng
dc.subjectCerrahi Tıp Bilimleri
dc.subjectTıp
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectCERRAHİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleProlactin-secreting carcinoma of the pituitary: clinicopathological and immunohistochemical study of a case with intracranial and intraspinal dissemination
dc.typeMakale
dc.relation.journalBRITISH JOURNAL OF NEUROSURGERY
dc.contributor.department, ,
dc.identifier.volume11
dc.identifier.issue4
dc.identifier.startpage350
dc.identifier.endpage355
dc.contributor.firstauthorID22442


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