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Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study

dc.contributor.authorYESILBURSA, Dogan
dc.contributor.authorOzbek, Ugur
dc.contributor.authorÇİNE, NACİ
dc.contributor.authorTURKCAN, Solmaz
dc.contributor.authorAtalar, Fatmahan
dc.contributor.authorONCU, Fatih
dc.contributor.authorAcuner, Tufan Tevfik
dc.date.accessioned2021-03-03T14:44:38Z
dc.date.available2021-03-03T14:44:38Z
dc.identifier.citationAtalar F., Acuner T. T. , ÇİNE N., ONCU F., YESILBURSA D., Ozbek U., TURKCAN S., "Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study", BEHAVIORAL AND BRAIN FUNCTIONS, cilt.6, 2010
dc.identifier.issn1744-9081
dc.identifier.othervv_1032021
dc.identifier.otherav_3b33b2b8-43d0-4482-b146-3f03fb8ba258
dc.identifier.urihttp://hdl.handle.net/20.500.12627/43761
dc.identifier.urihttps://doi.org/10.1186/1744-9081-6-27
dc.description.abstractBackground: The pathobiology of schizophrenia is still unclear. Its current treatment mainly depends on antipsychotic drugs. A leading adverse effect of these medications is the acquired long QT syndrome, which results from the blockade of cardiac HERG1 channels (human ether-a-go-go-related gene potassium channels 1) by antipsychotic agents. The HERG1 channel is encoded by HERG1 (KCNH2, Kv11.1) gene and is most highly expressed in heart and brain. Genetic variations in HERG1 predispose to acquired long QT syndrome. We hypothesized that the blockade of HERG1 channels by antipsychotics might also be significant for their therapeutic mode of action, indicating a novel mechanism in the pathogenesis of schizophrenia.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectDavranış Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectDAVRANIŞ BİLİMLERİ
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectNEUROSCIENCES
dc.titleTwo four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study
dc.typeMakale
dc.relation.journalBEHAVIORAL AND BRAIN FUNCTIONS
dc.contributor.departmentIstanbul Bakirkoy Mental Health & Neurology Training & Research Hospital , ,
dc.identifier.volume6
dc.contributor.firstauthorID59648


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