dc.contributor.author | YESILBURSA, Dogan | |
dc.contributor.author | Ozbek, Ugur | |
dc.contributor.author | ÇİNE, NACİ | |
dc.contributor.author | TURKCAN, Solmaz | |
dc.contributor.author | Atalar, Fatmahan | |
dc.contributor.author | ONCU, Fatih | |
dc.contributor.author | Acuner, Tufan Tevfik | |
dc.date.accessioned | 2021-03-03T14:44:38Z | |
dc.date.available | 2021-03-03T14:44:38Z | |
dc.identifier.citation | Atalar F., Acuner T. T. , ÇİNE N., ONCU F., YESILBURSA D., Ozbek U., TURKCAN S., "Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study", BEHAVIORAL AND BRAIN FUNCTIONS, cilt.6, 2010 | |
dc.identifier.issn | 1744-9081 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_3b33b2b8-43d0-4482-b146-3f03fb8ba258 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/43761 | |
dc.identifier.uri | https://doi.org/10.1186/1744-9081-6-27 | |
dc.description.abstract | Background: The pathobiology of schizophrenia is still unclear. Its current treatment mainly depends on antipsychotic drugs. A leading adverse effect of these medications is the acquired long QT syndrome, which results from the blockade of cardiac HERG1 channels (human ether-a-go-go-related gene potassium channels 1) by antipsychotic agents. The HERG1 channel is encoded by HERG1 (KCNH2, Kv11.1) gene and is most highly expressed in heart and brain. Genetic variations in HERG1 predispose to acquired long QT syndrome. We hypothesized that the blockade of HERG1 channels by antipsychotics might also be significant for their therapeutic mode of action, indicating a novel mechanism in the pathogenesis of schizophrenia. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler | |
dc.subject | Sosyal ve Beşeri Bilimler | |
dc.subject | Davranış Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | DAVRANIŞ BİLİMLERİ | |
dc.subject | Sinirbilim ve Davranış | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | NEUROSCIENCES | |
dc.title | Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study | |
dc.type | Makale | |
dc.relation.journal | BEHAVIORAL AND BRAIN FUNCTIONS | |
dc.contributor.department | Istanbul Bakirkoy Mental Health & Neurology Training & Research Hospital , , | |
dc.identifier.volume | 6 | |
dc.contributor.firstauthorID | 59648 | |