Show simple item record

dc.contributor.authorDisbudak, Murat
dc.contributor.authorSahin, Yucel
dc.contributor.authorAksoy, Hall
dc.contributor.authorYardimci, K. Turay
dc.contributor.authorFresko, Izzet
dc.contributor.authorAlturfan, A. Ata
dc.contributor.authorTETİK, ŞERMİN
dc.contributor.authorAhmad, Sarfraz
dc.date.accessioned2021-03-03T14:46:50Z
dc.date.available2021-03-03T14:46:50Z
dc.date.issued2010
dc.identifier.citationTETİK Ş., Ahmad S., Alturfan A. A. , Fresko I., Disbudak M., Sahin Y., Aksoy H., Yardimci K. T. , "Determination of oxidant stress in plasma of rheumatoid arthritis and primary osteoarthritis patients", INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, cilt.47, sa.6, ss.353-358, 2010
dc.identifier.issn0301-1208
dc.identifier.othervv_1032021
dc.identifier.otherav_3b6bb174-dae8-480b-9431-deb5115d7df8
dc.identifier.urihttp://hdl.handle.net/20.500.12627/43909
dc.description.abstractDetermination of oxidant stress in plasma of rheumatoid arthritis (RA) and primary osteoarthritis (POA) patients is important in understanding the pathogenesis of these diseases. In this study, we examined the relationship between oxidant stress and inflammation by measuring protein carbonyl content, thiol levels and plasma protein fractions as the oxidation markers and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) tests as inflammation markers. Protein carbonyls content was higher in RA and POA patients, as compared to controls (p < 0.0001), while the plasma thiol levels in both groups of patients were significantly lower than controls (p < 0.0001). Increased levels of proteins under 40 kDa molecular mass were detected in the RA and POA patients compared to that of controls (p < 0.0001) both in HPLC and SDS-PAGE analysis. Total protein concentration in plasma of RA patients was higher than the controls (p < 0.001), while in POA patients was lower than that of controls (p < 0.001). ESR and CRP levels were higher in both the patient groups than the normal group (p < 0.001). These results suggested that alterations in the oxidant stress markers could be the cause of inflammation in these diseases. Thus, while working for RA/POA treatment strategies, consideration of the relationship between oxidant stress and inflammation would be worth evaluating.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBİYOFİZİK
dc.subjectBiyoloji ve Biyokimya
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyofizik
dc.subjectBiyokimya
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.titleDetermination of oxidant stress in plasma of rheumatoid arthritis and primary osteoarthritis patients
dc.typeMakale
dc.relation.journalINDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume47
dc.identifier.issue6
dc.identifier.startpage353
dc.identifier.endpage358
dc.contributor.firstauthorID198624


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record